Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (40): 7593-7596.doi: 10.3969/j.issn.1673-8225.2011.40.043

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ABO-incompatible peripheral hematopoietic stem cell transplantation in 10 cases

Jin Ha-si1, Lu Yan-xia1, Tao Ge Si Hua2, Gong Li-ping3, Mu Li-xin4   

  1. 1Department of Hematology, General Hospital of Armed Police Forces, Beijing  100039, China
    2Zhong Meng Hospital of Wulate Qian Qi, Bayan Nur  014400, Inner Mongolia Autonomous Region, China
    3Department of Pathology, Capital Mediacl University, Beijing  100612, China
    4Capital Airport Hospital, Beijing  100090, China
  • Received:2011-03-10 Revised:2011-04-20 Online:2011-10-01 Published:2011-10-01
  • Contact: Mu Li-xin, Master, Attending physician, Capital Airport Hospital, Beijing 100090, China
  • About author:Jin Ha-si☆, Doctor, Associate chief physician, Department of Hematology, General Hospital of Armed Police Forces, Beijing 100039, China wujingjhs@yahoo.com.cn

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Abstract:

BACKGROUND: During ABO-incompatible peripheral hematopoietic stem cell transplantation, it is very important to observe the change of blood type of patients and to select correct blood type in transfusion.
OBJECTIVE: To observe the clinical effect and short-term and long-term complications in ABO-incompatible allogeneic peripheral hematopoietic stem cell transplantation.
METHODS: Ten patients after ABO-incompatible peripheral hematopoietic stem cell transplantation were enrolled between 2005 and 2008. Transplantation effect, blood changes, graft-versus-host disease and adverse reactions were analyzed after the trasplantation.
RESULTS AND CONCLUSION: Nine patients had hematological recovered after transplantation, and their blood types were changed to donors’ blood types. One patient had delayed red blood cell engraftment and developed pure red cell aplasia. One patient developed severe graft-versus-host disease. Transient hemoglobinuria, severe acute hemolysis and non-delayed hemolysis did not occur. ABO-incompatible peripheral hematopoietic stem cell transplantation has no apparent impact on transplant outcomes. Strategies to prevent and treat pure red cell aplasia are very important.

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