Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (40): 7589-7592.doi: 10.3969/j.issn.1673-8225.2011.40.042

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Effect of autologous bone marrow mesenchymal stem cell transplantation on motor development of cerebral palsy children

Chen Wen-ming1, Hu Yun-xin1, Yin Jing-yu2, Lu Jian-jun1, Wang Jian2, Zou Qing-yan3   

  1. 1Department of Neurology, 2Department of Cerebral Palsy, 3Laboratory of Neurology, Guangdong 999 Brain Hospital, Guangzhou  510510, Guangdong Province, China
  • Received:2011-04-08 Revised:2011-06-30 Online:2011-10-01 Published:2011-10-01
  • About author:Chen Wen-ming★, Master, Associate chief physician, Department of Neurology, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong Province, China wenming6311@tom.com

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Abstract:

BACKGROUND: Previous clinic studies demonstrated bone marrow mesenchymal stem cells (BMSCs) could play a role in treating nervous system diseases; however, the effect of BMSCs on treating cerebral palsy has been less reported.
OBJECTIVE: To analyze the effect of autologous BMSCs transplantation on the promotion of motor development in cerebral palsy children. 
METHODS: A total of 34 cerebral palsy children were divided into control and treatment groups according to the wishes of their parents. Treatment group received autologous BMSCs transplantation plus rehabilitation training, while the control group only underwent rehabilitation training. The modified Gross Motor Function Classification Measure (GMFM) was performed before treatment and after 3 months treatment.
RESULTS AND CONCLUSION: The GMFM scores increased significantly in the two groups after 3 months treatment (P < 0.01). The increment of GMFM scores in the treatment group was more than that in the control group after 3 months treatment. Autologous BMSCs transplantation is effective, and may play an active role in the motor development in cerebral palsy children.

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