Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (37): 6967-6971.doi: 10.3969/j.issn.1673-8225.2011.37.030

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Effects of Bizhongxiao decoction on extracellular signal-regulated kinase 1/2 and 5 expression in the synovial tissue in a rat model of collagen-induced arthritis

Xu Ze-lin1, Liang Qing-hua1, Chen Jiang2, Xiong Xin-gui1, Guo Ya-jing1, Xiao Yu-mei1   

  1. 1Institute of Combined Traditional Chinese and Western Medicine, 2Remote Medical Center, Xiangya Hospital of Central South University, Changsha   410008, Hunan Province, China
  • Received:2011-02-15 Revised:2011-02-21 Online:2011-09-10 Published:2011-09-10
  • Contact: Liang Qing-hua, Professor, Doctoral supervisor, Institute of Combined Traditional Chinese and Western Medicine, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China lqhxy@126.com Correspondence to: Chen Jiang, Master, Engineer, Remote Medical Center, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China cjxyz@126.com
  • About author:Xu Ze-lin★, Studying for master’s degree, Institute of Combined Traditional Chinese and Western Medicine, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China 751825767@qq.com
  • Supported by:

    Ph.D. Programs Foundation of Ministry of Education of China, No. 200805330011*; Science and Technology Plan Program of Hunan Province, No. 2009SK3163*; Traditional Chinese Medicine Foundation of Hunan Province, No. 2010038*

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Abstract:

BACKGROUND: Abnormal signal transduction of synovial cells is one of important pathogeneses of rheumatoid arthritis (RA). Chinese herbs Bizhongxiao decoction exhibits satisfactory clinical curative effects in treatment of RA. It is necessary to investigate the mechanism by which Bizhongxiao decoction treats RA at the level of cellular signal transduction.
OBJECTIVE: To investigate the effects of Bizhongxiao decoction on extracellular signal-regulated kinase (ERK) 1/2 and ERK 5 expression in the synovial tissue in a rat model of collagen-induced arthritis.
METHODS: Forty-five SD rats were randomly divided into three groups: control, model and Bizhongxiao deconction. Rat models of collagen-induced arthritis were intragastrically administered with 3.0-3.5 mL Bizhongxiao decoction, once a day, for successive 14 days. At 14, 21 and 28 days after arthritis induction, ERK 1/2 and ERK 5 expression was detected.
RESULTS AND CONCLUSION: After arthritis induction, ERK 1/2 and ERK 5 expression in the synovial tissue was increased with elongation of time (P < 0.05). After Bizhongxiao decoction treatment, ERK 1/2 and ERK 5 expression levels were significantly decdreased (P < 0.05). Results showed that Bizhongxiao decoction can inhibit the activation of ERK1/2, and ERK 5 and thereby inhibit the activation of ERK 1/2 and ERK 5 signal transduction pathway. This may be one of important mechanisms by which Bizhongxiao decoction inhibits abnormal proliferation of synovial tissue and the erosion of articular bone in RA.

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