Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (37): 6923-6926.doi: 10.3969/j.issn.1673-8225.2011.37.020

Previous Articles     Next Articles

Effects of different doses of selenium-rich water on the proliferation of hypertrophic scar fibroblasts

Hu Qing-quan1, Xiong Hui2, Zou Li-jin3, Zhang You-lai3, Li Yu-cong1, Zeng Yuan-lin3   

  1. 1Medical College of Nanchang University, Nanchang  333006, Jiangxi Province, China
    2Jiangxi Vocational and Technical College of Nursing, Nanchang  330006, Jiangxi Province, China
    3Burn Center, First Affiliated Hospital of Nanchang University, Nanchang  330006, Jiangxi Province, China
  • Received:2011-03-08 Revised:2011-04-28 Online:2011-09-10 Published:2011-09-10
  • Contact: Zeng Yuan-lin, Professor, Chief physician, Burn Center, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China zengyuanlin777@ yahoo.com.cn
  • About author:Hu Qing-quan★, Studying for master’s degree, Physician, Medical College of Nanchang University, Nanchang 333006, Jiangxi Province, China huqingquan@126. com
  • Supported by:

    2007 Plan Program of Health Department of Jiangxi Province, No.20073200*

PDF

346

Abstract:

BACKGROUND: Clinical studies have shown that selenium-rich water can obviously inhibit hypertrophic scar.
OBJECTIVE: To investigate the effects of selenium-rich water on the proliferation of human hypertrophic scar fibroblasts (HSFBs).
METHODS: Human HSFBs were cultured by the tissue explants method. Passages 3-5 human HSFBs were cultured with 10%, 20% and 30% selenium-rich water, running water and distilled water for 48 hours. Cell proliferation was measured by MTT method.
RESULTS AND CONCLUSION: Human HSFBs cultured with selenium-rich water were reduced in number, cell processes were shortened to different extents or lacked, and cytoplasm and nucleus were reduced. Different doses of selenium-rich water, running water, and distilled water exhibited inhibitory effects on the proliferation of human HSBFs, in particular selenium-rich water and in a dose-dependent manner (P < 0.05). Results showed that selenium-rich water inhibits the proliferation of human HSFBs in a dose-dependent manner.

CLC Number: