Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (36): 6683-6686.doi: 10.3969/j.issn.1673-8225.2011.36.008

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Immunomodulatory abilities of bone marrow-derived and adipose-derived mesenchymal stem cells

Zhu Xi-shan, Tai Wei-ping, Shi Wei, An Guang-yu   

  1. Department of Tumor, Beijing Shijitan Hospital of Capital Medical University (The 9th Hopital of Peking University), Beijing  100038, China
  • Received:2011-03-14 Revised:2011-06-15 Online:2011-09-03 Published:2011-09-03
  • About author:Zhu Xi-shan☆, Doctor, Department of Tumor, Beijing Shijitan Hospital of Capital Medical University (The 9th Hopital of Peking University), Beijing 100038, China zhuxishan@tsinghua.org.cn

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Abstract:

BACKGROUND: Do adipose-derived mesenchymal stem cells (ADMSCs) have a similar role with bone marrow mesenchymal stem cells (BMSCs) in immune regulation?
OBJECTIVE: To observe the immunological characteristics of ADMSCs and BMSCs.
METHODS: ADMSCs and BMSCs were isolated to detect T cell cycle, activation, inhibition and proliferation.
RESULTS AND CONCLUSION: BMSCs and ADMSCs have the same function to inhibit T cell proliferation in mitogen-stimulated and mixed lymphocyte reaction of T cell proliferation in a dose-dependent manner: a strong inhibitory effect was found at a ratio of 1:2, but disappeared at a ratio of 1:100. Coculutre of BMSCs and ADMSCs could inhibit more T cells in the G0/G1 stage, and simultaneously inhibit the early activation of T cell. But the role of ADMSCs was less than that of BMSCs and ADMSCs could not inhibit T-cell apoptosis alone.

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