Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6379-6381.doi: 10.3969/j.issn.1673-8225.2011.34.026

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Preparation and size control of biotinylated polymeric nanoparticles by dialysis method

Li Zi-ling, Xiong Xiang-yuan, Gong Yan-chun, Li Yu-ping   

  1. College of Life Science, Jiangxi Science & Technology Normal University, Nanchang  330013, Jiangxi Province, China
  • Received:2011-03-07 Revised:2011-05-17 Online:2011-08-20 Published:2011-08-20
  • Contact: Xiong Xiang-yuan, Doctor, Professor, College of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi Province, China xyxiong@gmail.com
  • About author:Li Zi-ling★, Master, Lecturer, College of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi Province, China Lzlowen2010@gmail.com
  • Supported by:

    the National Natural Science Foundation of China, No. 50763003 *

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Abstract:

BACKGROUND: Few reports about the particle size control by dialysis method have been published in China.
OBJECTIVE: To investigate the effect of preparation method and condition on particle size.
METHODS: Biotinylated polymeric nanoparcticles were prepared by a dialysis method. The particle size was compared by one-factor experimental design.
RESULTS AND CONCLUSION: The size of polymeric nanoparticles obtained from the addition of organic phase into water is pretty suitable for their application in drug delivery carriers. In addition, the amount of initial organic solvent plays an important role in the particle size.

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