Abstract:

BACKGROUND: There is no injected drug dosage form listing because of solubility and hemolysis problem of ibuprofen.
OBJECTIVE: To put ferrofluid into magnetic solid lipid nanoparticles (MSLN) so as to prepare ibuprofen-MSLN. 
METHODS: The optimal formulation was obtained by orthogonal experiment design, based on the encapsulate efficiency (EE%). Fe3O4 magnetic fluid was perpared with co-precipitation method as magnetic materials. Ibuprofen-MSLN was finally acquired with the method of emulsification dispersion-ultrasound. The appearance, the size distribution, Zeta potential, saturation magnetization, EE% and in vitro release characteristics were observed. 
RESULTS AND CONCLUSION: The optimal formulation was ibuprofen 0.05 g, F-68 0.2 g, Tween 80 0.05 g, lecithin 0.1 g, glyceryl monostearate 0.05 g, ferrofluid 2.5 mL. The ibuprofen-MSLN was uniformly spherical; the average size and Zeta potential were (122±16) nm and (-13.3±6.94) mV, respectively; the EE% of ibuprofen and ferroso-ferric oxide were 84.15% and 83.19%, respectivley; the release of ibuprofen-MSLN was complete in the given media in 36 hours. Ibuprofen-MSLN prepeared by this condition and technology is consistent with the demand of nano-preparations.