Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6252-6256.doi: 10.3969/j.issn.1673-8225.2011.33.042

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Association between adiponectin gene single nucleotide polymorphisms and bone mineral density in a male population of Zhuang nationality in Guangxi Baise area

Wang Jin-hua1, Huang Xiu-feng1, Zhou Qing-hui1, Lin Chao-wen1,Yang Yuan-yuan1, Wei Ye-sheng2, Huang Chang-sheng1, Wu Lian-tao3, Wu Yu-mei3, He Lan-feng1   

  1. 1Institude of Anthropology, 2Affiliated Hospital,3 Grade 2008 Undergraduate Clinical Medicine, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
  • Received:2011-04-25 Revised:2011-07-04 Online:2011-08-13 Published:2011-08-13
  • Contact: Huang Xiu-feng, Professor, Institude of Anthropology, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China hxflcw@163.com
  • About author:Wang Jin-hua★, Master, Lecturer, Institude of Anthropology, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China wangjinhua98@126. com
  • Supported by:

    the National Natural Science Foundation of China, No. 30860117*; Science and Technology Plan Program of Guangxi Zhuang Autonomous Region, No. (Guikegong08980040)guikejizi[2008]98*; High-Tech Research and Development Program of Youjiang Medical University for Nationalities, No.[2008]2*

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Abstract:

BACKGROUND: Studies have shown that adiponectin plays an important role in bone metabolism, but the relationship between adiponectin gene polymorphism and bone metabolism in osteoporosis has rarely been reported.
OBJECTIVE: To investigate the correlation between adiponectin gene 5 single nucleotide polymorphisms and bone mineral density in Guangxi Zhuang nationality men.
METHODS: A case-control study was carried out on osteopenia patients. Genotypes for adiponectin gene 5 loci (rs1063539, rs12495941, rs266729, rs3774261 and rs710445) polymorphism in 302 Guangxi Zhuang nationality men were determined by Multiplex SNaPshot.
RESULTS AND CONCLUSION: rs1063539, rs12495941, rs266729 and rs710445 polymorphisms were met with Hardy-Weinberg equilibrium (P> 0.05). Five loci genotype frequencies in the normal group and the osteopenia group met with Hardy-Weinberg equilibrium (P > 0.05). There was no significant difference in the genotype distributions of five loci polymorphism between low bone mass group and control group (P > 0.05). After adjustments for age, weight, height, movement and body mass index, multivariate Logistic regression analyses revealed that only rs3774261 polymorphism remained significantly associated with low bone mass   (P < 0.01). The subjects with the combined AA genotype had higher risk of low bone mass compared with those with the AG+GG genotype (adjusted OR =1.948, 95%CI: 1.184-3.203, P=0.009). Polymorphism of rs3774261 was independently correlated with calcaneal low bone mass in Baise Zhuang nationality male population. The results confirm that, adiponectin gene intron 2 rs3774261 polymorphism and bone mineral density in Baise Zhuang nationality men have some relevance. The presence of the AA genotype may dominantly increase the risk of osteopenia. AG+GG genotype has a protective effect on bone mineral density. The data also suggest that the rs1063539, rs12495941, rs266729 and rs710445 polymorphism might not be associated with osteopenia in Baise Zhuang nationality men.

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