Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6247-6251.doi: 10.3969/j.issn.1673-8225.2011.33.041

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Classical ancient recipe for patients with osteoporosis: A systematic review

Lu Yong1, Shi Liang1, Gao Zhen2, Li Chao2   

  1. 1Department of Orthopedics, 2National Clinical Research Base of Traditional Chinese Medicine, Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi  830000, Xinjiang Uygur Autonomous Region, China
  • Received:2011-04-11 Revised:2011-05-23 Online:2011-08-13 Published:2011-08-13
  • Contact: Li Chao, Master, Physician, National Clinical Research Base of Traditional Chinese Medicine, Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China Gaozhening@gmail.com
  • About author:Lu Yong, Chief physician, Doctoral supervisor, Department of Orthopedics, Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China goodies@yahoo.cn
  • Supported by:

    the Natural Science Foundation of Xinjiang Uygur Autonomous Region, No. 2011211A090*

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Abstract:

BACKGROUND: Classical ancient recipe shows satisfactory therapeutic effects in treatment of osteoporosis, but there are few reports describing systemic scientific methods for meta analysis to identify the general curative effects of classical ancient recipe.
OBJECTIVE: To evaluate the clinical curative effects and safety of classical ancient recipe in treatment of osteoporosis.
METHODS: A computer-based retrieval was performed in China National Knowledge Infrastructure, CPCD and Weipu databases for searcing papers addressing randomized controlled trials (RCTs) involving classical ancient recipe for treatment of osteoporosis published between 2001 and 2010. The Cochrane collaboration’s RevMan 4.2.2 software was used for data analyses.
RESULTS AND CONCLUSION: A total of 17 trials involving 1 235 patients were included. According to the Jadad scoring method, of the 17 RCTs, 4 studies scored 2 points, and the remaining studies each scored 1 point. According to the allocation concealment, all the 17 RCTs got C. In the meta-analysis, the classical ancient recipe treatment was significantly superior to western medicine treatment in total effective rate OR=3.82, 95%CI (2.70-5.41), symptom score WMD=-1.95, 95%CI (-2.19-1.72), lumbar vertebra bone minearal density WMD=0.04, 95%CI(0.03-0.06), and the other parts bone minearal density WMD=0.04, 95%CI (0.03-0.06). Classical ancient recipe plus western medicine treatment were significantly superior to western medicine treatment in total effective rate OR=3.09, 95%CI (1.58-6.07). The current clinical evidence shows that the classical ancient recipe treatment is superior in treatment of osteoporosis with no obvious adverse reactions.

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