Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6211-6215.doi: 10.3969/j.issn.1673-8225.2011.33.032

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Changes in maxillary structure and bone mass in osteoporosis rats with experimental periodontitis after Zuogui pill and estrogen treatment

Li Chun-nian, Li Shu-juan, Yang Dong-ru, Dong Fu-sheng, Wu Ming-xuan, Liu Qing   

  1. Department of Oral Medicine, Stomatological Hospital of Hebei Medical University,  Hebei Key  Laboratory of Oral Medicine, Shijiazhuang 050017, Hebei Province, China
  • Received:2011-03-06 Revised:2011-06-08 Online:2011-08-13 Published:2011-08-13
  • Contact: Yang Dong-ru, Chief physician, Professor, Department of Oral Medicine, Stomatological Hospital of Hebei Medical University, Hebei Key Laboratory of Oral Medicine, Shijiazhuang 050017, Hebei Province, China yangdr@hebmu.edu.cn
  • About author:Li Chun-nian★, Master, Attending physician, Department of Oral Medicine, Stomatological Hospital of Hebei Medical University, Hebei Key Laboratory of Oral Medicine Shijiazhuang 050017, Hebei Province, China lchunnian@163.com
  • Supported by:

    a grant from Traditional Chinese Medicine and Integrated Traditional and Western Medicine Program of Hebei Provincial Bureau of Traditional Chinese Medicine, No.2009107*

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Abstract:

BACKGROUND: Studies have shown that the classic kidney-tonifying prescription Zuogui pill can be used for treatment of osteoporosis in post-menopausal women.
OBJECTIVE: To observe the changes in maxillary structure and bone mass in osteoporosis rats with experimental periodontitis.
METHODS: Sprague-Dawley rat models of periodontitis were established by ligation of maxillary first molar under the anesthesia. Then osteoporosis was induced in these rat models by overiectomy. After 3 months, these rats were treated with Zuogui pill and estradiol valerate for 3 months.
RESULTS AND CONCLUSION: Both Zuogui pill and estradiol valerate promoted the neogenesis of alveolar bone, alleviated the inflammatory status of periodontal tissue (P < 0.05), reduced the osteoclasts (P < 0.05), elevated the osteoprotegerin level in the periodontal tissue (P < 0.01), and decreased the serum level of alkaline phosphatase (P < 0.01). These findings suggest that Zuogui pill and estrodiol valerate can improve the structure of alveolar bone and increase maxillary bone mass in osteoporosis rats with experimental periodontitis.

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