Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6207-6210.doi: 10.3969/j.issn.1673-8225.2011.33.031

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Effect of ligustrazine on nuclear factor kappa B and intercellular adhesion molecule-1 expression in a rat model of acute lung injury

Wang Jing-jing, Duan Fei, Zhang Zhi, Li Shao-chun, Liu Wei-hua, Huo Peng   

  1. Department of Histology and Embryology, School of Basic Medical Sciences, Hebei University, Baoding 071000, Hebei Province, China
  • Received:2011-04-22 Revised:2011-07-09 Online:2011-08-13 Published:2011-08-13
  • Contact: Duan Fei, Doctor, Professor, Doctoral supervisor, Department of Histology and Embryology, School of Basic Medical Sciences, Hebei University, Baoding 071000, Hebei Province, China feiduan9999@sina. com
  • About author:Wang Jing-jing★, Studying for master’s degree, Attending physician, Department of Histology and Embryology, School of Basic Medical Sciences, Hebei University, Baoding 071000, Hebei Province, China huayouwjj@yahoo. com.cn
  • Supported by:

    Science Foundation of Human Resource and Social Security Department of Hebei Province, No. 20100306*; a grant from Baoding Science and Technology Bureau, No.04F001(4)*

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Abstract:

BACKGROUND: Ligustrazine is quite effective in treating and preventing idiopathic pulmonary fibrosis (IPF), but there are few reports describing the mechanism by which ligustrazine treats acute lung injury.
OBJECTIVE: To observe the expression changes of nuclear factor-kappa B (NF-κB) and intercellular adhesion molecule-1(ICAM-1) in lung tissues of rats with acute lung injury induced by oleic acid.
METHODS: Rat models of acute lung injury were established by intravenous injection of oleic acid and then interfered with ligustrazine and dexamethasone.
RESULTS AND CONCLUSION: After successful induction of acute lung injury, the lung coefficient increased significantly in the model group compared with the control group (P < 0.05). Immunohistochemical staining results showed that NF-κB and ICAM-1 expression in the model group was significantly increased (P < 0.05). After ligustrazine and dexamethasone intervention, the above-mentioned changes were obviously alleviated (P < 0.05). These results suggest that ligustrazine exhibits an obvious protective effect on lung tissue during acute lung injury, and the mechanism might be related to the inhibition of NF-κB and ICAM-1 expression.

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