Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (33): 6203-6206.doi: 10.3969/j.issn.1673-8225.2011.33.030

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Effects of tanshinol on alveoar bone metabolism in rats

Zhang Xiao-yan1, Cui Liao1, Wu Tie1, Liu Yun-xin2   

  1. 1Department of Pharmacology, Guangdong Medical College, Dongguan   523808, Guangdong Province, China
    2Outpatient Department of Guangdong Medical College, Dongguan 523808, Guangdong Province, China
  • Received:2011-03-05 Revised:2011-06-09 Online:2011-08-13 Published:2011-08-13
  • Contact: Wu Tie, Professor, Master’s supervisor, Department of Pharmacology, Guangdong Medical College, Dongguan 523808, Guangdong Province, China Cui Liao, Professor, Doctoral supervisor, Department of Pharmacology, Guangdong Medical College, Dongguan 523808, Guangdong Province, China zxyivy611@163.com
  • About author:Zhang Xiao-yan★, Master, Lecturer, Department of Pharmacology, Guangdong Medical College, Dongguan 523808, Guangdong Province, China zxyivy611@163.com
  • Supported by:

    Technology Plan Key Program of Guangdong Province No.A301030201*

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Abstract:

BACKGROUND: Decrease in insulin-like growth factor 1 (IGF-1) is an early marker of bone loss.
OBJECTIVE: To determine the activity of IGF-1 in rat alveoar bone tissue and investigate the possible mechanism by which tanshinol prevents alveolar bone osteoporosis.
METHODS: Twenty-four Sprague-Dawley rats were randomly divided into three groups: sham-ovariectomized rats, ovariectomized rats and ovariectomized rats with tanshinol treatment (12.5 mg/kg per day). At 90 days after administration, alveolar bone tissue was taken for detection of bone mass and the activity of IGF-1 in alveolar bone tissue.
RESULTS AND CONCLUSION: Compared with sham-ovariectomized rats, alveolar bone mass was decreased significantly, percentage of trabecular bone was decreased by 33.88% (P < 0.05), trabecular separation was increased by 43.58% (P < 0.05) and IGF-1 expression was markedly decreased (P < 0.05) in ovariectomized rats. Compared with ovariectomized rats, alveoar bone mass was increased significantly, percentage of trabecular bone was increased by 45.45% (P < 0.05) and IGF-1 expression was markedly increased (P < 0.05) in ovariectomized rats with tanshinol treatment. These findings confirm that tanshinol can increase the expression of IGF-1 in alveolar bone tissue and prevent alveoar bone osteoporosis.

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