Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2825-2828.doi: 10.3969/j.issn.1673-8225.2011.15.040

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Correlation between Hind Ⅲ polymorphism of osteocalcin gene and bone mineral density in Han Chinese postmenopausal women in Fuzhou area

Nie Da-rong1, Wang He-ming2, Yang Lian-zi1, Peng Mei-yu2, Chen Ke3   

  1. 1Department of Orthopaedics, Second People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou  350003, Fujian Province, China
    2Fujian University of Traditional Chinese Medicine, Fuzhou  350108, Fujian Province, China
    3Fujian Institute of Traditional Chinese Medicine, Fuzhou  350003, Fujian Province, China
  • Received:2010-07-12 Revised:2010-12-12 Online:2011-04-09 Published:2013-11-06
  • About author:Nie Da-rong★, Studying for master’s degree, Attending physician, Department of Orthopaedics, Second People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China 944258053@qq.com
  • Supported by:

    the Education Department of Fujian Province in 2007, No. JA07128*

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Abstract:

BACKGROUND: Osteoporosis is a polygenic disease. The relationships between osteocalcin (OC) genotypes and bone mineral density (BMD) are different from regions and populations.
OBJECTIVE: To investigate the relationship between OC genotypes and BMD in postmenopausal women, so as to explore the susceptibility gene of female postmenopausal osteoporosis in Fuzhou region.
METHODS: The OC genotype was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The BMD of lumbar spine, femoral neck, trochanter and Ward’s triangle of 201 Han Chinese postmenopausal women were measured by dual energy X-ray absorptiometry. 
RESULTS AND CONCLUSION: The distribution of OC genotypes of Han Chinese postmenopausal women in Fuzhou followed the Hardy-Weinberg equilibrium (X2=2.29, P > 0.05). The frequencies of OC polymorphism were HH genotype 5%, hh 46%, and Hh 49%, which was not significant different from those of Fuzhou, Beijing, Guangzhou and Taiwan (P > 0.05), but obviously different from Japanese and Caucasians (P < 0.05). There was a significant difference in BMD of trochanter between HH and hh genotypes (P < 0.05), but the difference was not significant in vertebrae L2-4, femoral neck and Ward’s triangular area. There is some association between OC genotypes and BMD in postmenopausal women possibly.

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