Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2800-2804.doi: 10.3969/j.issn.1673-8225.2011.15.034

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Fibroblast growth factors and organogenesis

Ou Ming-ming, Huang Xiao-feng, Han Pei-yan   

  1. Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Received:2010-11-08 Revised:2011-01-10 Online:2011-04-09 Published:2013-11-06
  • Contact: Huang Xiao-feng, Doctor, Associate chief physician, Associate professor, Master’s supervisor, Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China hxf1998@hotmail.com
  • About author:Ou Ming-ming★, Studying for master’s degree, Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China ommmqx@163.com
  • Supported by:

    the Beijing New Star Project on Science and Technology, No. 2007B54*; the Basic-clinical Cooperation of Capital Medical University, No. 20095L022*; Program for Excellent Talents in Beijing, No. 2010D003034000012*

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Abstract:

BACKGROUND: Fibroblast growth factor (FGF) has many effects on differentiation, proliferation, apoptosis and other functions during development of different organs.
OBJECTIVE: To review the functions of FGF during development of different organs, and to provide theoretical basis for further study.
METHODS: Articles were retrieved from PubMed and CNKI database with the key words of “FGF, tooth development, kid and ney development, lung development, salivary gland development” both in English and Chinese from the year of 1995 to 2010 2001 to 2010 respectively. Studies concerning the structure, function of FGF and relative organogenesis were included. Literatures about the same circle published in the near future or on the authoritative journals were included.
RESULTS AND CONCLUSION: A total of 850 documents were collected, and 37 English articles and 2 Chinese papers were summarized. The initial development of tooth, lung, kidney, feather, hair follicle, cardiovascular and salivary gland arises from the interaction between the epithelial and mesenchymal cells. FGF plays important roles on enhancement of interaction, induction of cell proliferation and differentiation, inhibition of cell death, etc, during organogenesis.

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