Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2794-2797.doi: 10.3969/j.issn.1673-8225.2011.15.032

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Expression of proliferating cell nuclear antigen and C-Fos protein in fetal stomach tissues

Liu Xue-hong   

  1. School of Medicine, Shaoxing University, Shaoxing  312000, Zhejiang Province, China
  • Received:2010-09-30 Revised:2010-10-15 Online:2011-04-09 Published:2013-11-06
  • About author:Liu Xue-hong★, Master, Lecturer, School of Medicine, Shaoxing University, Shaoxing 312000, Zhejiang Province, China
  • Supported by:

    the Science and Technology Plan of Education Department of Zhejiang Province in 2008, No. Y200805569*; the Science and Technology Item of Shaoxing University, No. 08LG1018*

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Abstract:

BACKGROUND: High expression of proliferating cell nuclear antigen (PCNA) can promote cell DNA synthesis and reflect condition of cell proliferation. C-Fos combined with DNA can directly regulate transcription factors, which promote cell growth, differentiation and proliferation during development of embryonic cells.
OBJECTIVE: To explore the expression of PCNA and C-Fos proteins in the stomach tissues of human fetus.
METHODS: The PCNA and C-Fos positive cells in the stomach tissues of human fetus were tested in the second, third and fourth month of fetal periods by the immunohistochemical methods. And the integral absorbance (IA) was analyzed with Nikon imaging system (NIS-DR).
RESULTS AND CONCLUSION: The positive expressions of PCNA and C-Fos protein were detected in the all of layers of human fetal stomach in the second, third and fourth month of fetal periods. With the fetal age increasing, the expression of IA of PCNA positive cells showed an up- then down-trend, but positive expression of C-Fos protein gradually increased (P < 0.01). PCNA and C-fos proteins play an important role in regulating the growth and development of human fetal stomach tissues.

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