Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2790-2793.doi: 10.3969/j.issn.1673-8225.2011.15.031

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Influence of focal adhesion kinase signaling pathway on formation of traumatic deep vein thrombosis

Mo Jian-wen1, Hu Hai-lan2, Bai Bo1, Li Ying1, Zhang Shu-jiang1, Chen Yi1, Deng Jin-jing1   

  1. 1Department of Orthopaedics, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou  510120, Guangdong Province, China
    2Department of Orthopaedics, the Second Hospital of Guangzhou Medical College, Guangzhou  510260, Guangdong Province, China
  • Received:2010-11-25 Revised:2011-01-30 Online:2011-04-09 Published:2013-11-06
  • Contact: Bai Bo, Professor, Department of Orthopaedics, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, Guangdong Province, China drbobai@yahoo.com
  • About author:Mo Jian-wen☆, Doctor, Department of Orthopaedics, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, Guangdong Province, China mjw1997@126.com
  • Supported by:

    the Natural Science Foundation of Guangdong Province, No. 9151018201000035*

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Abstract:

BACKGROUND: The molecular mechanism of traumatic deep vein thrombosis is complex. The influence of focal adhesion kinase (FAK) signaling pathway on the development of deep vein thrombosis remains poorly understood.
OBJECTIVE: To study the effects of FAK signaling pathway in traumatic deep vein thrombosis.
METHODS: Twenty SD rats were prepared for femoral fracture models and divided into 2 groups according to thrombosis states, namely, the thrombosis and no thrombosis groups, with 10 animals in each group. Additional 10 rats served as controls. The femoral vein was incised and total RNA was extracted. The femoral vein RNA expression was detected by Genechip Rat genome 430 2.0 genechips, and the changes of FAK signaling pathway gene was analyzed. 
RESULTS AND CONCLUSION: Compared with no thrombosis group, the key genes of thrombosis group related to FAK signaling pathway of extracellular matrix, protein kinase C, Fyn, actinin and Vav were up-regulated, and integrinα, myosin light chain phosphatase and c-Jun were down-regulated. FAK signaling pathway may be one of the most important pathways to control the biological states of thrombus.

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