Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2786-2789.doi: 10.3969/j.issn.1673-8225.2011.15.030

Previous Articles     Next Articles

Xianlinggubao for treatment of osteoporotic rats: Serological and bone histomorphometric evaluation

Xing Lei1, Jiao Ying-hua2, Geng Li-hua1, Sun Yao1   

  1. 1Department of Senile Disease, 2Department of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of North China Coal Medical University, Tangshan  063000, Hebei Province, China
  • Received:2010-12-07 Revised:2011-03-01 Online:2011-04-09 Published:2013-11-06
  • Contact: Sun Yao, Professor, Chief physician, Department of Senile Disease, Affiliated Hospital of North China Coal Medical University, Tangshan 063000, Hebei Province, China sunyao59@yahoo. com.cn
  • About author:Xing Lei★, Master, Attending physician, Department of Senile Disease, Affiliated Hospital of North China Coal Medical University, Tangshan 063000, Hebei Province, China xlpangdun001@163.com

PDF

543

Abstract:

BACKGROUND: The treatment for osteoporosis mainly targeted on inhibition of bone-resorption at present, Xianlinggubao (XLGB) was reported to be effective for promoting bone formation, but the detail mechanism remains unclearly.
OBJECTIVE: To investigate the effects of XLGB on bone mass, biomechanical properties and bone metabolism of osteoporotic rats induced by ovariectomy.
METHODS: Twenty-four rats were randomized into 3 groups: normal control group, bilateral ovariectomized group (model), and XLGB treatment group. Rats received bilateral ovariectomized operation except those in the control group. Six weeks later, rats in XLGB group were administered with XLGB, and in the model group administered with distilled water. Content of procollagen typeⅠN-terminal propeptide (PINP) in blood serum and dihydropyrimidine dehydrogenase/creatinine (DPYD/Cr), N-telopeptide of typeⅠcollagen/creatinine (NTX/Cr) in urine were detected at 4 weeks after operation, the left femurs were collected for bone mineral density test, and left tibias were prepared for the measurement of bone histomorphometry.
RESULTS AND CONCLUSION: Compared with the model group, the levels of PINP, DPYD/Cr, NTX/Cr, number of osteoclasts and absorption percentage (P < 0.05), but the proximal bone mineral density and bone trabecula volume was dramatically increased (P < 0.05). The results demonstrated that XLGB could partly prevent bone loss in ovariectomized rats by inhibiting bone resorption and promoting bone formation, thereby reduce the bone turnover level.

CLC Number: