Abstract:

BACKGROUND: Contents of total flavonoids are closely related to species. It is an effective method to research pharmacodynamic mechanism of traditional Chinese medicine by combining Chinese medicine flavone with minor element for anti-free radical.
OBJECTIVE: To study the content and antioxidation of flavone in 16 kinds of Chinese medicine, and to explore the effects of flavone synergized with zinc on anti-free radical. 
METHODS: The contents of total flavones in 16 kinds of traditional Chinese medicine were extracted using alcohol extraction and measured by UV. The oxidation resistance effect of total flavone synergized with zinc on anti-free radical was determined.
RESULTS AND CONCLLUSION: There were certain variation of total flavones contents in different kinds of invigorating qi and promoting blood circulation traditional Chinese medicine, the contents as follows: salvia miltiorrhiza > giant knotweed > red peony root > trumpetweed > sufficient jade > white peony root > ginkgo leaf > ligusticum chuanxiong hort > achyranthes root > Chinese angelica > motherwort > rhodobryum roseum > codonopsis pilosula > milkvetch root > ginseng > curcuma longa L., but all the Chinese medicine could suppress superoxide anion radical. Most of traditional Chinese medicine increased the effect of oxidation resistance after zinc synergism, especially ginseng flavones, which increased 7-fold. The results demonstrated that the drug action of invigorating qi and promoting blood circulation traditional Chinese medicine may relates to zinc synergism.