Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (11): 1977-1980.doi: 10.3969/j.issn.1673-8225.2011.11.019

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Comparison of two microvessels markers CD34 and CD105 in microvasculature of pathological scars

Huang Ru-lin1, Liang Jie2, Xia Qiong-ping1, Huang Qi-li1, Wu Zhi-xian2   

  1. 1Department of Plastic Surgery, the Second People’s Hospital of Zhuhai, Zhuhai  519000, Guangdong Province, China
    2Institute of Plastic Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang  524001, Guangdong Province, China
  • Received:2010-09-28 Revised:2010-10-15 Online:2011-03-12 Published:2011-03-12
  • Contact: Liang Jie, Master, Professor, Master’s supervisor, Institute of Plastic Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China liangjieplasitc@163. com
  • About author:Huang Ru-lin★, Master, Physician, Department of Plastic Surgery, the Second People’s Hospital of Zhuhai, Zhuhai 519000, Guangdong Province, China hrl222@163.com
  • Supported by:

    the Natural Science Foundation of Guangdong Province, No. 06028957*

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Abstract:

BACKGROUND: There is not a reliable neovascularization marker for pathological scar. Though CD34 and CD105 are considered to be a credible vascular endothelial cell marker, they have own specially features.
OBJECTIVE: The difference between the two microvessels marker CD34 and CD105 in microvasculature of pathological scar.
METHODS: Immunohistochemistcal staining for the CD34 and CD105 was performed in normal skin tissue specimens, non-pathological scar tissue specimens, hypertrophic scar tissue specimens and keloid tissue specimens, the internal diameter (ID) of microvessels marked by CD34 and CD105 and the expression area of CD34 and CD105 were measured by image analysis software MoticImages Advanced 3.2, the morphology and distribution characteristics of mirovessels were analyzed after the photos taken by image acquisition instruments.
RESULTS AND CONCLUSION: In all of specimens, the ID of microvessels marked by CD34 and CD105 were (73.14±17.85) μm and (27.91±5.86) μm, respectively, the microvessels marked by CD105 were newer than the microvessels marked by CD34. As an endothelial marker of angiogenesis, CD105 is a more special marker for neovascularization than CD34 in pathological scar, CD105 could be considered to be a credible neovascularization marker.

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