Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (11): 1981-1985.doi: 10.3969/j.issn.1673-8225.2011.11.020

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Effect of innervation on scar formation after burn wound healing

Guo Peng-fei1, Zhang Rui2, Feng Yong-qiang1, Zhu Shou-rong1, Wang Yi-bing1   

  1. 1Department of Burn and Plastic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan  250021, Shandong Province, China; 2Department of Pathology and Pathophysiology, Shandong Medical College, Jinan  250021, Shandong Province, China
  • Received:2010-10-21 Revised:2011-01-15 Online:2011-03-12 Published:2011-03-12
  • Contact: Wang Yi-bing, Doctor, Professor, Chief physician, Master’s supervisor, Department of Burn and Plastic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China wyb0616@yahoo. com.cn
  • About author:Guo peng-fei★, Studying for master’s degree, Department of Burn and Plastic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China
  • Supported by:

    the Natural Science Foundation of Shandong Province, No. Y2002C29*

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Abstract:

BACKGROUND: Previous experiments show that neural factors play important regulating roles in wound healing, however, the relationship between neural regulation and scar formation after wound healing is known little.
OBJECTIVE: To observe the relationship between innervations and wound healing in the process of scalded wound healing.
METHODS: Right T9-L1 stage spinal nerve roots of 30 rats were cut off and prepared for denervation skin models; and then a diameter of 4 cm and a depth ofⅡdegree scalded wound was make on the right denervated skin area of rats (model group), the same wounds were made on the left normal skin as control group. The changes of wounds were continuously observed. The secretion of type Ⅰ, Ⅲ collagens were observed by immunohistochemical method, and type Ⅰ/Ⅲ collagen ratios were calculated, the speed and quality of wound healing was explored.
RESULTS AND CONCLUSION: Compared with the control group, the type I/III collagen ratio was lower in the model group (P < 0.05). Secretion of type Ⅰ collagen gradually increased in the model group at 7, 14 and 21 days after injury (P < 0.05), and type III collagen was significantly increased at 21 days after injury (P < 0.05). Type Ⅰ / Ⅲcollagen ratio was significantly decreased at 21 days after injury (P < 0.05). It is revealed that early innervation of the wound may promote wound healing, and alleviating innervation on wound remodeling stage may improve the quality of wound remodeling.

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