Abstract:

BACKGROUND: Results of white blood cell WBC, hemoglobin, and platelet, rather than reticulocyte (RET) or mean platelet volume (MPV) are observed to study the recovery of patients after liver transplantation. 
OBJECTIVE: To explore change laws of RET, immature reticulocyte fraction (IRF), blood platelets count (BPC), and MPV in Child-Pugh grading patients with orthotopic liver transplantation during perioperative stage and the recovery period, and to analyze the relationship to Child-Pugh classification.
METHODS: Totally 129 cases with end-stage liver diseases were divided into Child-Pugh 5-6 score group (n=44), Child-Pugh 7-9 score group (n=48) and Child-Pugh 10-15 score group (n=37). All the samples were obtained at preoperative stage and at 1, 3, 5, 7, 10, 15 and 30 days after transplantation. The RET, IRF, BPC and MPV were measured by Sysmex XE-2100 hematology analyzer and compared with control group.
RESULTS AND CONCLUSION: It showed that RET% and IRF in patients at preoperative stage was significantly higher in the case groups than that of control group, which increased with Child integrate raises. The RET% was increased and then decreased, but IRF increased after transplantation, both of them reached a peak at 7 days after transplantation. It observed that BPC was related to Child-pugh classification, the serious pathogenetic condition lead to low BPC and larger MPV. The BPC was gradually increased from the Child-Pugh 5-6 score group to Child-Pugh 10-15 score group after experiencing a period of low value after transplantation. The findings demonstrated that RET and platelet indicators have an important reference value for judging therapeutic effect in Child-Pugh grading patients and predicting bone marrow functions after liver transplantation.