Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (5): 792-795.doi: 10.3969/j.issn.1673-8225.2011.05.008

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Comparison of patients’ renal function in the process of living donor liver transplantation and cadaveric liver transplantation

Qin Zhao-jun, Zhan Le-yun, Jiang Jian-li, Deng Cai-ying, Lü En   

  1. Department of Anesthesiology, People’s Hospital, China Three Gorges University, Yichang   443000, Hubei Province, China
  • Received:2010-07-28 Revised:2010-11-17 Online:2011-01-29 Published:2011-01-29
  • About author:Qin Zhao-jun★, Master, Attending physician, Department of Anesthesiology, People’s Hospital, China Three Gorges University, Yichang 443000, Hubei Province, China qin1172001@yahoo.com.cn

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Abstract:

BACKGROUND: Many factors during orthotopic liver transplantation may lead to acute postoperative renal failure. However, the effect of different surgical procedures on intraoperative renal function is unclear.
OBJECTIVE: To compare the effect of living-related partial liver transplantation and cadaveric liver transplantation on renal function of patients in the process of transplantation.
METHODS: Fifteen end-stage liver disease adult patients with living-related partial liver transplantation are set to living donor group who received piggyback orthotopic liver transplantation; and the other 20 patients with whole cadaveric donor liver transplantation are set to cadaveric donor group at the same time who received classic orthotopic liver transplantation without venovenous bypass. Hemodynamics and renal function parameters were measured immediately before incision, at 1 hour after incision, 30 minutes after clamping portal vein, 1 hour and 4 hours after unclamping portal vein, respectively.
RESULTS AND CONCLUSION: There were no significant differences in both mean arterial pressure (MAP) and heart rate (HR) at each time point between the living donor and cadaveric donor groups (P > 0.05). Compared with cadaveric donor group, both cardiac output (CO) and cardiac index (CI) at 30 minutes after clamping portal vein were significantly higher in living donor group; however, systemic vascular resistance (SVR) and systemic vascular resistance index (SVRI) at 30 minutes anhepatic phase were lower in living donor group than that of the cadaveric donor group (P < 0.05). Serum Cystatin C, β2-microglobulin, creatinine, and creatinine clearance rate (CCR) were all within normal range at all time points in the process of transplantation between the living donor and cadaveric donor groups. There were no significant differences between the total volume of urine and furosemide dosage (P > 0.05). But urine volume per minute during anhepatic phase in living donor group was much more than in cadaveric donor group (P < 0.05). It is indicated that living-related partial liver transplantation and cadaveric donor liver transplantation have no adverse effects on renal function of patients in the process of transplantation.

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