Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (31): 5729-5732.doi: 10.3969/j.issn.1673-8225.2010.31.008

Previous Articles     Next Articles

Expression of lymphocyte subsets and immune balance in recipients following liver transplantation

Zhang Yong-ming, Hu Wei-yu, Li Yong, Hao Jian-shuai, Wu Li-qun   

  1. Department of Hepatobiliary Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao  266003, Shandong Province, China
  • Online:2010-07-30 Published:2010-07-30
  • Contact: Wu Li-qun, Doctor, Doctoral supervisor, Chief physician, Department of Hepatobiliary Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China wulq5810@126.com
  • About author:Zhang Yong-ming★, Master, Department of Hepatobiliary Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China zym19820809@126.com
  • Supported by:

    the Key Tackle Item for Science and Technology Development of Qingdao, No. 06-2-2-6-nsh-1*

PDF

445

Abstract:

BACKGROUND: Documents reported that the peripheral blood lymphocyte changes are more sensible than hepatic enzymes changes following liver transplantation, but its specificity needs further explored.
OBJECTIVE: To study the relationship among the levels of CD3-/HLA-DR+, CD3+/CD25+ and CD3+/HLA-DR-, the immune status of the recipients, and complications in recipients after liver transplantation.
METHODS: The liver functions and lymphocyte subsets in 56 recipients were detected by the automatic biochemical analyzer and flowcytometry. The recipients were divided into 2 groups (normal and abnormal groups) according to liver function. And the recipients in the abnormal group were divided into the acute rejection group (n=7), drug reaction group (n=11) and unknown reasons group (n=9). The levels of CD3-/HLA-DR+, CD3+/CD25+ and CD3+/HLA-DR- in patients after liver transplantation of each group were measured, and  the relationship of their levels and complications were analyzed.
RESULTS AND CONCLUSION: The expression of CD3-/HLA-DR+ and CD3+/CD25+ in the normal group was lower than that in the abnormal group (P =0.011, 0.002), while the expression of CD3+/HLA-DR- was higher in the normal group (P=0.012). And the expression of CD3-/HLA-DR+ and CD3+/CD25+ in the acute rejection group was greater than those in the drug reaction group (P=0.039, 0.048), but the expression of CD3+/HLA-DR- was higher in acute rejection group (P=0.007). There were a significantly correlations between the expression of CD3-/HLA-DR+, CD3+/CD25+ and CD3+/HLA-DR- and the immune status and complications of recipients, they may be a factor to assess the complications and adjust the immune status of recipients after liver transplantation.

CLC Number: