Abstract:

BACKGROUND: The condition of fatty liver has closely relationship with transplantation results in living donor liver transplantation. How to evaluate fatty liver with noninvasive method has great importance.
OBJECTIVE: To evaluate the possibility and safety of body mass index (BMI), B ultrasound and CT examination in evaluating fatty liver graft before living donor liver transplantation.
METHODS: The clinical data including 38 cases with living donor liver transplantation were retrospective analyzed. BMI, preoperative assessment of abdominal B ultrasound and CT were recorded and compared with intraoperative liver biopsy pathology reports.
RESULTS AND CONCLUSION: The biopsy pathology showed that, there were 8 cases with mild fatty liver, and 3 cases with moderate fatty liver. According to the diagnostic criteria, namely, BMI ≥ 25 kg/m2 as mild fatty liver, there were 12 cases with fatty liver. Compared with pathological results, the specificity of BMI was 41.7% and sensitivity was 45.4%, of which had 100% sensitivity and 60% specificity in diagnosing moderate fatty liver. Preoperative CT diagnosis showed 9 cases had fatty liver, and the specificity was 44.4% and sensitivity 36.4%. Preoperative ultrasound diagnosis showed 5 cases had fatty liver, with 60% specificity, and 27.7% sensitivity. There were great differences among BMI, B ultrasound, CT and donor liver biopsy in evaluating fatty liver graft before living liver transplantation. Preoperative ultrasound diagnosis had relatively high specificity, and preoperative BMI diagnosis had relatively high specificity. Accordingly, it is needed to conduct comprehensive assessment with three methods, and transhepatic pathological examination could be performed if necessary.