Abstract:

BACKGROUND: It arouses increasing attention on the safety of donors and the transplant results with the growth of living-relative donor kidney transplantation.
OBJECTIVE: To summarize the clinical experiences of 40 cases with living-relative donor kidney transplantation and to evaluate the effect and reliability.
METHODS: Totally 40 cases received living-relative donor kidney transplantation at the Department of Transplantation and Urinary Surgery, Ruikang Hospital Affiliated to Guangxi Chinese Traditional Medicine College from June 2007 to August 2008 were included. The relevant clinical data of the donors and the recipients were reviewed and analyzed. Meantime, 40 cases received cadaveric renal transplantation at corresponding time period were selected as controls. The differences of recovery times of serum creatinine, occurrence rates of acute rejection, delayed graft function, related complication were compared.
RESULTS AND CONCLUSION: The operating times of all donors were 1.0-2.0 hours, the warm ischemic time of donor kidney was about 15 seconds, and the cold ischemic times were 1.0-2.0 hours. No surgical complication and medical complication occurred during the peri-operation period. The kidney function of recipient recovered rapidly after operation. The urine volume in the first three days was 500-1 000 mL/h, and all of the creatinine levels could be restored to normal in 1 week. Up till now, all donors and recipients survived. Moreover, the functions of transplanted kidney were in normal range. Compared with the 40 cases with cadaveric kidney transplantation in the same period, the donors of living-relative donor kidney transplantation have more advantages in the following aspects: shorter recover time for creatinine, lower occurrence rates of acute rejection and delayed graft function after transplantation. Moreover, the living-relative donor kidney transplantation is charactered by shorter ischemic time of donor kidney and operative duration. The open operation in living donor nephrectomy also has the advantage of reliability.