Debridement, antibiotics, and implant retention combined with replacement of assembled components in treatment of acute prosthetic joint infection after total hip arthroplasty

doi:10.12307/2025.163

Abstract

Abstract: BACKGROUND: Lifespan of prosthetic joint was being influenced by periprosthetic infection after total hip arthroplasty. Combination of debridement, antibiotics, and implant retention with the replacement of assembled components represents a novel approach in the management of acute prosthetic joint infection after total hip arthroplasty.
OBJECTIVE: To observe the efficacy of debridement, antibiotics, and implant retention combined with the replacement of assembled components in the treatment of acute prosthetic joint infection after total hip arthroplasty.
METHODS: Twenty-two patients with acute prosthetic joint infection after initial total hip arthroplasty at the Department of Orthopedics, Huangshi Central Hospital, China, between July 2018 and February 2022 were enrolled. The infection time of all patients was less than 3 weeks after the initial arthroplasty. Intraoperative joint fluid extraction and bacterial culture of infected synovium proved to be acute stage infection. They were treated using debridement, antibiotics, and implant retention combined with the replacement of assembled components. Infections were assessed using leukocyte count, erythrocyte sedimentation rate, and C-reactive protein levels before, 3 and 6 months after surgery. Improvements in hip joint function were evaluated using Harris hip score. Pain relief was assessed using visual analog scale score. Paired sample t-test was used to analyze the improvement of each index before and after operation.
RESULTS AND CONCLUSION: (1) One patient died of non-periprosthesis infection and was subsequently lost to follow-up, which was excluded. The remaining 21 patients received clinical follow-up, and the follow-up time was more than 1 year, with a mean follow-up time of (19.52±3.88) months. Among them, 20 patients were successfully treated with surgery and 1 patient failed, and the infection control rate was 95%. (2) The levels of leukocyte count, erythrocyte sedimentation rate, and C-reactive protein were lower in 3 and 6 months after surgery (P < 0.05); Harris hip function scores were higher than those before surgery (P < 0.05); pain visual analog scale scores were lower than those before surgery (P < 0.05), and the differences were significant (P < 0.05). (3) It is indicated that debridement, antibiotics, and implant retention combined with the replacement of assembled components after total hip arthroplasty in patients with acute prosthetic joint infection can effectively control prosthetic joint infection, improve hip function, and relieve hip pain caused by infection.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: total hip arthroplasty, debridement, antibiotics, and implant retention, prosthetic joint infection, assembled components, hip function score

CLC Number:

Pan Xian, Zhang Yuanjin, Zhang Guofu, Li Jun, Liu Bingxia, Zhou Dingkang, Sun Farui. Debridement, antibiotics, and implant retention combined with replacement of assembled components in treatment of acute prosthetic joint infection after total hip arthroplasty[J]. Chinese Journal of Tissue Engineering Research, 2025, 29(21): 4499-4505.

Figures/Tables 4

References

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