Chinese Journal of Tissue Engineering Research ›› 2022, Vol. 26 ›› Issue (23): 3670-3675.doi: 10.12307/2022.666
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Qian Xiaofen1, Zeng Ping2, Liu Jinfu2, Chen Cai1, Fan Siqi2, Nong Jiao2, Deng Wei2
Received:
2021-08-14
Accepted:
2021-09-18
Online:
2022-08-18
Published:
2022-02-23
Contact:
Zeng Ping, MD, Chief physician, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, Guangxi Zhuang Autonomous Region,China
About author:
Qian Xiaofen, Master candidate, Graduate school of Guangxi University of Chinese Medicine, Nanning 530299, Guangxi Zhuang Autonomous Region, China
Supported by:
CLC Number:
Qian Xiaofen, Zeng Ping, Liu Jinfu, Chen Cai, Fan Siqi, Nong Jiao, Deng Wei. Comprehensive analysis of competing endogenous RNA network and potential biomarkers in alcohol-induced osteonecrosis of the femoral head[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(23): 3670-3675.
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2.3 lncRNA靶基因预测结果 对lncRNA进行靶基因预测发现有10个lncRNA可以找到205个miRNA,并通过FunRich3.1.3查找到5 184个mRNA靶点。 2.4 ceRNA网络构建结果 预测的5 184个mRNA与作者所鉴定的921个mRNA有258个交集基因,最后仅保留lncRNA与mRNA表达呈正相关的RNA构建ceRNA网络,见图5,包括3个lncRNA(SNHG3、MUC19、LINC00476)、5个miRNA(hsa-miR-146b-5p、hsa-miR-139-5p、hsa-miR-126-3p、hsa-miR-193a-3p、hsa-miR-135a-5p)和11个mRNA(PEX5、ACTR3B、CHMP4B、CSMD1、MTRF1、ZNF3、HTR7、NR5A2、SYT14、CASK、ING5),见表2。"
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