Association of bone mineral density and skeletal muscle with fracture risks in postmenopausal women in Inner Mongolia area

doi:10.12307/2022.472

Abstract

Abstract: BACKGROUND: The increased risk of osteoporotic fracture is independent of bone mineral density, whereas the effects of muscle and fat on the fracture risk have not been quantitatively assessed.
OBJECTIVE: To identify the relationship between bone mineral density, muscle and the risk of osteoporotic fracture in postmenopausal women.
METHODS: Clinical data from 1 032 postmenopausal women, aged 40-49 years, who were admitted at the Second Affiliated Hospital of Inner Mongolia Medical University, were collected and analyzed. The bone mineral density and body composition were measured by dual-energy x-ray absorptiometry, and the fracture risks at the major sites in the next 10 years were assessed using the Fracture Risk Assessment Tool (FRAX®), released by the World Health Organization.
RESULTS AND CONCLUSION: The mean age of all the subjects was 64 years (range, 40 to 90 years). Mean bone mineral densities of the lumbar spine, femoral neck, and total hip were (0.78±0.16), (0.64±0.14), and (0.76±0.15) g/cm2, respectively. The appendicular lean mass and appendicular lean mass index were (15.9±2.4) kg and (6.57±1.77) kg/m2 respectively. The fracture risk calculated in 10 years by using the FRAX for hip fracture and major fracture was 4.2% (2.8%, 6.9%) and 1% (0.3%, 2.4%), respectively. The appendicular lean mass index showed a negative association with major fracture and hip fracture risks (P < 0.05). All these findings indicate that the appendicular lean mass index associated with an increased risk of a major fracture or hip fracture.

Key words: postmenopausal women, osteoporosis, bone miner density, muscle, fat, fracture risk

CLC Number:

Lin Jing, A Sileng, Dong Mei. Association of bone mineral density and skeletal muscle with fracture risks in postmenopausal women in Inner Mongolia area[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(14): 2133-2137.

Figures/Tables 5

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