Chinese Journal of Tissue Engineering Research ›› 2022, Vol. 26 ›› Issue (10): 1490-1494.doi: 10.12307/2022.192

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Kyphoplasty with high viscosity bone cement for the treatment of stage III Kümmell disease without neurological symptoms: restoration of vertebral body height, reduction of kyphoplasty and restoration of column sagittal sequence

Shi Yan1, Zhang Yunqing2, Liu Yong2, Rui Min2, Liu Shanglou2   

  1. 1Affiliated Jiangyin Clinical College of Xuzhou Medical University, Jiangyin 214400, Jiangsu Province, China; 2Department of Spinal Surgery, Affiliated Jiangyin Clinical College of Xuzhou Medical University, Jiangyin 214400, Jiangsu Province, China 
  • Received:2020-09-22 Revised:2020-09-23 Accepted:2020-11-11 Online:2022-04-08 Published:2021-10-25
  • Contact: Zhang Yunqing, Chief physician, Master’s supervisor, Department of Spinal Surgery, Affiliated Jiangyin Clinical College of Xuzhou Medical University, Jiangyin 214400, Jiangsu Province, China
  • About author:Shi Yan, Master candidate, Affiliated Jiangyin Clinical College of Xuzhou Medical University, Jiangyin 214400, Jiangsu Province, China

Abstract: BACKGROUND: Percutaneous kyphoplasty is widely used in the treatment of stage I and II Kümmell disease, which can rapidly relieve pain, stabilize vertebral body and correct kyphosis; however, the treatment of stage III Kümmell disease is still controversial.
OBJECTIVE: To evaluate the clinical outcome of kyphoplasty with high-viscosity bone cement for treatment of stage III Kümmell disease without neurologic symptoms. 
METHODS: Twenty-eight patients (11 males and 17 females, aged 57-82 years) with stage III Kümmell disease without neurologic symptoms were admitted to Jiangyin People’s Hospital from May 2016 to May 2019, in which T11 vertebral body in 6 cases and T12 vertebral body in 14 cases, L1 vertebral body in 5 cases and L2 vertebral body in 3 cases were treated by kyphoplasty with high viscosity bone cement. At 1 day after operation and 1 year after follow up, postoperative pain and improvement of life ability were evaluated by the Visual Analogue Scale and Oswestry Disability Index. The recovery of vertebral height and correction of kyphosis were measured with X-ray films. The study was approved by the Ethics Committee of Jiangyin People’s Hospital, approval No. [2017](021). 
RESULTS AND CONCLUSION: (1) Totally 28 patients were followed up for 12-22 months. No serious complications such as wound infection or pulmonary embolism were found during treatment. Asymptomatic cement leakage occurred in three patients. Adjacent vertebral fracture was encountered in 1 patient at 3 months after operation, and healed after kyphoplasty. (2) Visual Analogue Scale, Oswestry Disability Index, and kyphotic angle were lower at 1 day and 1 year after operation than those before operation in 28 patients (P < 0.05). The height of anterior, middle and posterior edges of vertebral body at 1 day and 1 year after operation was higher than that before operation (P < 0.05). (3) The results showed that kyphoplasty with high-viscosity bone cement can relieve back pain, improve viability, retain the vertebral body height, reduce kyphosis, and restore spinal alignment, and is an effective method for treatment of stage III Kümmell disease. 

Key words: bone, material, bone cement, Kümmell disease, kyphoplasty

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