Relationship between tacrolimus metabolic rate and early BK virus infection after kidney transplantation

doi:10.12307/2022.116

Abstract

Abstract: BACKGROUND: BK virus is a kind of polyomavirus. In recent years, with the widely application of new powerful immunosuppressants, BK virus infection rate is continuously rising after renal transplantation. Kidney diseases caused by BK virus nephropathy have become one of the important reasons for renal allograft loss. However, there is a lack of effective antiviral drugs to prevent or treat BK virus nephropathy. Identifying the high-risk population of BK virus infection after kidney transplantation will help in the timely detection and early prevention and control of BK virus nephropathy.
OBJECTIVE: To study the relationship between the metabolic rate of tacrolimus and early BK virus infection after kidney transplantation.
METHODS: A total of 62 kidney transplant recipients from January 2017 to December 2018 in Air Force Hospital of PLA Northern Theater Command were selected for detection of CYP3A5 gene polymorphism by gene sequencing, and then were divided into fast metabolites (CYP3A5*1/*1 or *1/*3 genotype; n=28) and slow metabolites (CYP3A5*3/*3 genotype; n=34), according to the gene detection results. All surgeries were approved by the Ethics Committee of the Air Force Hospital of PLA Northern Theater Command. The study protocol was also approved by the Ethics Committee of Air Force Hospital of Northern Theater Command.
RESULTS AND CONCLUSION: The tacrolimus metabolic rates at 1, 3, 6 and 12 months after surgery were significantly lower in the fast metabolite group than the slow metabolite group, and the incidence rates of BK viruria and BK virus nephropathy were similar between the two groups. These findings suggest that kidney transplant recipients with CYP3A5*1/*1 and *1/*3 genotypes have a higher risk of early BK viremia after kidney transplantation than those with CYP3A5*3/*3 genotypes.

Key words: kidney transplantation, tacrolimus, CYP3A5 genetic polymorphism, BK virus

CLC Number:

Yang Zhiwei, Liu Junchang, Gao Xiaolin, Jiang Taimao. Relationship between tacrolimus metabolic rate and early BK virus infection after kidney transplantation[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(5): 712-716.

Figures/Tables 6

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