Serum inflammatory mediators and oxidative stress in patients with type C distal radius fractures treated with external fixator combined with mid-frequency pulse therapy

doi:10.12307/2021.326

Abstract

Abstract: BACKGROUND: Type C distal radius fractures are often treated with external fixation. However, some patients still have undesirable symptoms such as delayed fracture healing and slow growth of callus. How to promote fracture healing and recovery of wrist joint function after surgery is of great significance.
OBJECTIVE: To investigate the effect of mid-frequency pulse therapy combined with external fixator on type C distal radius fracture and its influence on oxidative stress and inflammatory mediators.
METHODS: Clinical data of 86 patients with type C distal radius fracture admitted in Guangdong Provincial People’s Hospital from January to December 2018 were analyzed retrospectively. Patients were divided into two groups according to different treatment methods: external fixation group (n=41 cases) and combined group (mid-frequency pulse therapy combined with external fixation treatment, n=45 cases). The clinical effect of different treatment methods was observed, and the changes of serum inflammatory mediators and oxidative stress indexes before and 4 weeks after treatment were compared between the two groups.
RESULTS AND CONCLUSION: (1) The quantitative score of callus in the combined group was higher than that in the external fixation group, and the visual analogue scale score and Gartland-Werley score were lower than that in the external fixation group (P < 0.05). (2) At 4 weeks after treatment, malondialdehyde and advanced oxidation protein product levels decreased, and the level in the combined group was lower than that in the external fixation group (P < 0.05). The level of antioxidant glutathione peroxidase and superoxide dismutase levels increased; the level in the combined group was higher than that in the external fixation group (P < 0.05). (3) At 4 weeks after treatment, the levels of C-reactive protein, interleukin-6, and interleukin-1 β in the serum of the two groups were significantly lower than those before treatment (P < 0.05), and the levels in the combined group were lower than those in the external fixation group (P < 0.05). (4) It is concluded that mid-frequency pulse therapy combined with external fixator can promote the healing of type C distal radius fracture and the functional recovery of wrist joint, reduce postoperative inflammation and oxidative stress.

Key words: mid-frequency pulse therapy, external fixator, type C, distal radius fracture, oxidative stress, inflammatory mediators

CLC Number:

Li Jia, Fu Tingting, Ma Yuanchen, Liu Xiangqian, Chen Min. Serum inflammatory mediators and oxidative stress in patients with type C distal radius fractures treated with external fixator combined with mid-frequency pulse therapy[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(33): 5351-5355.

Figures/Tables 6

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