Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (34): 5517-5522.doi: 10.12307/2021.249

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Biological advantages of biodegradable microspheres in bone regeneration

Ma Shiqing, Wang Jie, Gao Ping, Liu Zihao   

  1. Dental Hospital, Tianjin Medical University, Tianjin 300070, China
  • Received:2020-12-29 Revised:2020-12-30 Accepted:2021-02-05 Online:2021-12-08 Published:2021-07-28
  • Contact: Liu Zihao, PhD, Lecturer, Dental Hospital, Tianjin Medical University, Tianjin 300070, China
  • About author:Ma Shiqing, PhD, Attending physician, Dental Hospital, Tianjin Medical University, Tianjin 300070, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81701019 (to MSQ); General Project of Tianjin Education Committee, No. 2019KJ173 (to LZH)

Abstract: BACKGROUND: Biodegradable microspheres, which release the functional modification factors encapsulated in them through self-degradation, can improve the drug solubility, half-life and other properties. They are widely used in the research of bone defect repair and regeneration.
OBJECTIVE: To review and summarize the application of biodegradable microspheres in bone regeneration, the advantages and disadvantages of various materials used to prepare microspheres, as well as the new technology and modification methods of microspheres.
METHODS: CNKI, Wanfang, PubMed, Elsevier, and Web of Science database were retrieved using “biodegradable microsphere, nanoparticle, bone regeneration, osteogenic” as English and Chinese keywords.
RESULTS AND CONCLUSION: In the research of bone regeneration, the materials used to prepare biodegradable microspheres include inorganic materials, natural polymer materials and synthetic polymer materials. The preparation methods include ionic gel, solvent evaporation, spray drying, phase separation, and sol-gel method. Although the microspheres have excellent biocompatibility and bone conductivity, the osteogenic properties of most of the materials are still not ideal. Many ways are used to modify the microspheres, such as loading osteogenic factor, anti-infective factor and angiogenic factor, making it possible to functionalize the microspheres. The optimization of microsphere processing technology, the construction of composite microspheres and composite scaffolds, and the introduction of new efficient modification factors all provide new ideas for the application of microsphere in bone regeneration.

Key words: microspheres, drug controlled-release, scaffold materials, nanomaterials, guided bone regeneration, growth factor, anti-infective, angiogenesis

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