Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (34): 5413-5419.doi: 10.12307/2021.232

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Preparation and degradation properties of concentrated growth factor fibrin membrane

Xiao Deli1, Sun Yinzhe1, Cui Cheng1, Liu Bo2   

  1. 1School of Science, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, China; 2Xiao Mei Kou Qiang Clinic in Nanle County, Puyang 457400, Henan Province, China
  • Received:2020-05-25 Revised:2020-05-26 Accepted:2020-09-21 Online:2021-12-08 Published:2021-07-26
  • Contact: Xiao Deli, PhD, Associate professor, School of Science, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, China
  • About author:Xiao Deli, PhD, Associate professor, School of Science, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, China
  • Supported by:
    the Achievements of National Innovation and Entrepreneurship Training Program for College Students, No. 202010316020G (to SYZ)

Abstract: BACKGROUND: The degradation time of biomaterials is crucial in the clinical application of guided bone regeneration surgery.

OBJECTIVE: To systematically compare the difference in degradation performance of platelet-rich fibrin membrane and concentrated growth factor membrane in vitro, and analyze the effects of different machines of the same type and different blood collection tubes on the degradation performance of concentrated growth factor membrane.

METHODS: Platelet-rich fibrin membranes and concentrated growth factor membranes were prepared with a Multi-CGF-3 centrifuge, and soaked in saliva to observe the changes in membrane quality and area. Two centrifuges of the same type were used to prepare concentrated growth factor membranes, which were then soaked in saliva to observe changes in membrane quality and area. Two types of vacuum blood collection tubes (BD tube and Kangjie tube) were used to prepare concentrated growth factor membranes, and the membranes were soaked in saliva to observe changes in membrane quality and area.
RESULTS AND CONCLUSION: (1) The in vitro degradation performance of the platelet-rich fibrin membrane and concentrated growth factor membrane was different. The initial mass of the concentrated growth factor membrane was larger and its degradation time in vitro was longer. (2) The initial mass of the concentrated growth factor membranes prepared by different machines of the same type had no significant difference. The smaller the initial area-to-mass ratio, the slower the degradation rate of the concentrated growth factor membrane. (3) Compared with the Kangjie tube, the BD tube had a better layering effect on blood samples after centrifugation; however, the degradation time and overall degradation performance of concentrated growth factor membranes prepared by the two test tubes were similar. (4) The results show that, as the latest generation of autologous platelet-concentrated products, the concentrated growth factor membrane exhibits better degradation performance than the platelet-rich fibrin membrane. 


Key words: material, oral cavity, concentrated growth factor, fibrin film, platelet-rich fibrin, degradation in vitro

CLC Number: