中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (51): 9629-9634.doi: 10.3969/j.issn.2095-4344.2012.51.024

• 生物材料综述 biomaterial review • 上一篇    下一篇

纳米羟基磷灰石在骨科中的临床应用及作用机制

杨再清1, 2，雷云坤1, 2，孟增东1, 2   

  • 出版日期:2012-12-16 发布日期:2012-12-16

Therapeutic implication of nano-hydroxyapatite in orthopedics   

Yang Zai-qing1,2, Lei Yun-kun1,2, Meng Zeng-dong1,2   

  • Online:2012-12-16 Published:2012-12-16

PDF

720

被引次数

9

摘要：

背景：纳米羟基磷灰石是一种具有代表性的生物活性材料，是现在组织工程领域研究的一个热点。
目的：综述纳米羟基磷灰石在骨科领域的临床应用进展，并探讨其作用机制。
方法：查阅2001年1月至2011年12月 CNKI 数据库和PubMed数据库有关纳米羟基磷灰石对成骨细胞、破骨细胞的影响及再血管化的研究，并总结其在骨科的临床应用进展。
结果与结论：纳米羟基磷灰石能够提高成骨细胞的增殖活性及功能代谢，诱发新骨形成；而破骨细胞能够吸收、降解羟基磷灰石，同时，纳米羟基磷灰石调节破骨细胞的代谢过程，共同参与了骨代谢。另外，纳米羟基磷灰石植入体内后能够再血管化，进而有利于骨修复和重建。基于纳米羟基磷灰石及其复合材料的优越性，是一种较为理想的骨缺损修复材料，已初步应用于临床，并取得了令人鼓舞的效果，但仍有许多问题有待于进一步研究解决。

Abstract:

BACKGROUND: Nano-hydroxyapatite is a representative bioactive material, which has been the focus of tissue engineering research.
OBJECTIVE: To review the orthopedic application and mechanism of nano-hydroxyapatite.
METHODS: CNKI and PubMed databases (2001-01/2011-12) were retrieved for articles related to the effect of nano-hydroxyapatite on osteoblasts, osteoclasts, and revascularization to summarize the clinical progress of nano-hydroxyapatite in orthopedics.
RESULTS AND CONCLUSION: Nano-hydroxyapatite can enhance the proliferation activity and functional metabolism of osteoblasts, and induce new bone formation. However, osteoclasts can absorb and degrade hydroxyapatite, and meanwhile, nano-hydroxyapatite can regulate osteoclast's metabolic processes and they influence each other in the bone metabolism. In addition, after implantation, nano-hydroxyapatite can be revascularized quickly and completely that is conducive to bone repairing and rebuilding. In view of the superiorities of nano-hydroxyapatite and its composite materials, nano-hydroxyapatite is an ideal material for repairing bone defects and has been preliminarily used in clinic. But there are still many problems to be solved in the future.