中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (14): 3061-3069.doi: 10.12307/2025.620

• 组织构建综述 tissue construction review • 上一篇    下一篇

不同频率电刺激促进周围神经损伤的恢复

刘敏琦1,高明威1,褚晓蕾2,邢  政2,李世浩2,丁  宁1,李亚杰1,李  奇2   

  1. 1天津体育学院运动健康学院,天津市  301617;2天津大学天津医院康复医学科,天津市  300211
  • 收稿日期:2024-05-30 接受日期:2024-07-15 出版日期:2025-05-18 发布日期:2024-09-29
  • 通讯作者: 李奇,硕士,副主任医师,天津大学天津医院康复医学科,天津市 300211
  • 作者简介:刘敏琦,男,1999年生,天津市人,汉族,天津体育学院在读硕士研究生,主要从事运动康复、周围神经损伤、周围神经病理性疼痛研究。
  • 基金资助:
    国家重点研发计划“生物与信息融合(BT与IT融合)”重点专项项目(2023YFF1205200),项目参与人:邢政;天津市自然科学基金面上项目(22JCYBJC00210),项目负责人:李奇;天津市自然科学基金面上项目(22JCYBJC00220),项目负责人:褚晓蕾

Different frequencies of electrical stimulation promote recovery from peripheral nerve injury

Liu Minqi1, Gao Mingwei1, Chu Xiaolei2, Xing Zheng2, Li Shihao2, Ding Ning1, Li Yajie1, Li Qi2     

  • Received:2024-05-30 Accepted:2024-07-15 Online:2025-05-18 Published:2024-09-29
  • Contact: Li Qi, MS, Associate chief physician, Department of Rehabilitation Medicine, Tianjin University Tianjin Hospital, Tianjin 300211, China
  • About author:1College of Exercise & Health, Tianjin University of Sport, Tianjin 301617, China; 2Department of Rehabilitation, Tianjin University Tianjin Hospital, Tianjin 300211, China Liu Minqi, Master candidate, College of Exercise & Health, Tianjin University of Sport, Tianjin 301617, China
  • Supported by:
    the National Key Research and Development Program of China under the Key Special Project of “Biology and Information Convergence (BT and IT Convergence),” No. 2023YFF1205200 (to XZ [project participant]); Tianjin Municipal Natural Science Foundation (General Programs), Nos. 22JCYBJC00210 (to LQ) and 22JCYBJC00220 (to CXL)

摘要:


文题释义:
沃勒变性:神经轴突因创伤断裂后,其远端的神经纤维发生的顺序性变化。由于轴浆运输被阻断,轴突断端远侧的部分很快自近端向远端发生变性、解体。
低频电刺激:低频电疗法是临床中应用广泛的电刺激治疗之一,应用频率1 000 Hz以下的电流作用于皮肤、肌肉或神经上。低频电疗法能够促进感觉、运动神经元恢复,缓解疼痛,改善患者的运动功能。

背景:电刺激是治疗周围神经损伤有效的治疗方案,但不同频率电刺激促进周围神经恢复的机制和应用不同。
目的:旨在系统梳理和总结不同频率电刺激在周围神经损伤治疗中的作用和应用,深入分析各种方法的优缺点,以期找到最有利于患者神经恢复的治疗策略。
方法:应用计算机检索中国知网、PubMed数据库自建库至2024年5月期间的相关文献,英文检索词为“peripheral nerve injury,electrical stimulation,low frequency electrical stimulation,medium frequency electrical stimulation,high frequency electrical stimulation,TENS,interfering electricity,short wave,ultrashort wave,frequency”,中文检索词为“周围神经损伤,电刺激,低频电刺激,中频电刺激,高频电刺激,干扰电疗法,短波,超短波,频率,周围神经再生”,最终纳入74篇文献进行分析。
结果与结论:周围神经损伤作为临床中常见的疾病,会引起患者感觉与运动功能障碍。低频电刺激能够促进电刺激后细胞增殖并加速细胞内神经生长因子表达,促进巨噬细胞募集和浸润,加速髓磷脂碎片的清除,促进受损轴突的髓鞘再生。中频电刺激能够作用于更深部位组织,对于缓解神经性疼痛方面更佳。高频电刺激能够促进施万细胞和巨噬细胞增殖并抑制炎性因子,更快募集到神经损伤部位,加快神经修复的速度。不同频率的电刺激在周围神经损伤恢复中各具优点,但是仍存在一些问题,例如电刺激的部位以及应对各种疾病类型的方案不同等。
https://orcid.org/0009-0000-2034-1492(刘敏琦)

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

关键词: 周围神经损伤, 电刺激, 频率, 低频电刺激, 神经再生, 周围神经

Abstract: BACKGROUND: Electrical stimulation is an effective treatment plan for peripheral nerve injuries, but different frequencies of electrical stimulation have different mechanisms and applications for promoting peripheral nerve recovery.
OBJECTIVE: To systematically sort out and summarize the roles and applications of different frequencies of electrical stimulation in the treatment of peripheral nerve injuries, and to deeply analyze the advantages and disadvantages of various methods in order to find the most beneficial treatment strategy for patients’ nerve recovery.
METHODS: Computer-based searches were conducted in the China National Knowledge Infrastructure (CNKI) and PubMed databases from the inception of the databases to May 2024. The search terms included “peripheral nerve injury, electrical stimulation, low frequency electrical stimulation, medium frequency electrical stimulation, high frequency electrical stimulation, TENS, interfering electricity, short wave, ultrashort wave, frequency” in both English and Chinese. Ultimately, 74 relevant documents were included for analysis.
RESULTS AND CONCLUSION: Peripheral nerve injury, a common clinical disease, can cause sensory and motor dysfunction in patients. Low-frequency electrical stimulation can promote cell proliferation and accelerate the expression of nerve growth factor within the cell after electrical stimulation, promote macrophage recruitment and infiltration, accelerate the clearance of myelin debris, and promote myelin regeneration of damaged axons. Medium-frequency electrical stimulation can act on deeper tissues and is better for relieving neuropathic pain. High-frequency electrical stimulation can promote the proliferation of Schwann cells and macrophages, inhibit inflammatory factors, and rapidly recruit cells to the site of nerve injury, accelerating the speed of nerve repair. Different frequencies of electrical stimulation have their own advantages in promoting the recovery of peripheral nerve injuries, but there are still some issues, such as differences in the site of electrical stimulation and the treatment plans for various disease types.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

Key words: peripheral nerve injury, electrical stimulation, frequency, low-frequency electrical stimulation, nerve regeneration, peripheral nerve

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