中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (30): 5556-5560.doi: 10.3969/j.issn.1673-8225.2011.30.012

• 骨科植入物 orthopedic implant • 上一篇    下一篇

桥接组合式金属内固定植入系统对犬骨折愈合的影响

熊  鹰，陆继鹏，李群辉，赵  烽，张  武   

  1. 昆明医学院附属延安医院骨科，云南省昆明市   650051
  • 收稿日期:2011-01-31 修回日期:2011-03-29 出版日期:2011-07-23 发布日期:2011-07-23
  • 通讯作者: 陆继鹏，硕士，主治医师，昆明医学院附属延安医院骨科，云南省昆明市650051 lujipeng_km@yahoo.com.cn
  • 作者简介:熊鹰，男，1958年生，重庆市人，汉族，1982年昆明医学院毕业，主任医师，主要从事脊柱外科及骨科内固定研究。
  • 基金资助:

    云南省教育厅科学研究基金资助项目(08C0113)。

Effects of bridge combined fixation system on healing of fractures in dogs 

Xiong Ying, Lu Ji-peng, Li Qun-hui, Zhao Feng, Zhang Wu    

  1. Department of Orthopedics, Kunming Yan’an Hospital Affiliated to Kunming Medical University, Kunming  650051, Yunnan Province, China
  • Received:2011-01-31 Revised:2011-03-29 Online:2011-07-23 Published:2011-07-23
  • Contact: Lu Ji-peng, Master, Attending physician, Department of Orthopedics, Kunming Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650051, Yunnan Province, China lujipeng_km@yahoo.com.cn
  • About author:Xiong Ying, Chief physician, Department of Orthopedics, Kunming Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650051, Yunnan Province, China
  • Supported by:

    the Scientific Research Fund of Yunnan Provincial Education Bureau, No. 08C0113*

PDF

399

被引次数

34

摘要：

背景：近年来内固定的研究主要从降低应力遮挡效应和减少血供破坏二方面展开。
目的：观察桥接组合式内固定系统对骨折愈合的影响。
方法：对20条家犬两侧胫骨中段横型截骨，随机选择一侧以桥接组合式内固定系统内固定，对侧以普通接骨钢板固定作为对照，分别于内固定后4，8，12，16周行大体病理、X射线摄片、光镜观察。
结果与结论：内固定后1，3周对照组分别出现骨折劈裂、钢板松脱和钢板断裂各1例，实验组术后5周出现内固定弯曲变形1例。实验组内固定后8周开始出现明显骨痂生长，对照组骨痂出现时间稍晚，各时期评分实验组均高于对照组，16周时差异有显著性意义(P< 0.05)。实验组纤维母细胞、新生毛细血管及骨痂的生长均早于对照组，各时期评分均高于对照组，8，16周时差异有显著性意义(P < 0.05)。结果表明，桥接组合式内固定系统能有效减少骨折端血供破坏，对骨折断端提供坚强动态的固定，有利于促进骨折愈合和骨改建。

关键词: 骨折固定, 内固定器, 骨折愈合, 犬, 动物实验

Abstract:

BACKGROUND: In recent years, studies concerning internal fixation mainly emphasize on reducing stress-shielding effect and damage to blood supply.
OBJECTIVE: To investigate the influence and mechanism of bridge combined fixation system (BCFs) on fracture healing.
METHODS: Bilateral tibia of 20 adult dogs were osteotomized in the middle and fixed with BCFs (experimental group) on left or right side at random, another side fixed with plate (control group). Five animals in each group were sacrificed at 4, 8, 12, 16 weeks after operation and observed with pathological examination, X-ray examination, and light microscopy.
RESULTS AND CONCLUSION: In the control group, fracture splitting, loose steel plate and steel fracture were found separately in one case at 3 weeks. While in the experimental group, flexural deformation was found in one case at 5 weeks. Callus could be observed with X-ray in the experimental group at 8 weeks, which was earlier than the control group. The X-ray grade of the experimental group were higher than that of the control group every period, and there were significant difference at 16 weeks (P <  0.05). Light microscopy showed that the quantity and quality of fibroblast, capillary vessel and callus of the experimental group were better than those of the control group. The hematoxylin-eosin stained grade of experimental group were higher than control group every period, there were prominent difference at 8 and 16 weeks (P  < 0.05). BCFs not only reduce the breakage of vessels near fracture part, but also afford firm and dynamic fixation for fracture fragment, which enhances healing and bone reconstruction.

中图分类号: