中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (28): 5210-5212.doi: 10.3969/j.issn.1673-8225.2011.28.020

• 组织构建实验造模 experimental modeling in tissue construction • 上一篇    下一篇

髋部骨折后下肢深静脉血栓形成家兔模型的建立

张  英，贾丙申，周建强，谭海涛，王  晟，付  昆，孟志斌   

  1. 海南医学院附属医院骨科，海南省海口市  570102
  • 收稿日期:2011-03-06 修回日期:2011-06-08 出版日期:2011-07-09 发布日期:2011-07-09
  • 通讯作者: 贾丙申，海南医学院附属医院骨科，海南省海口市570102 jbs123@163. com
  • 作者简介:张英，男，1968年生，海南省海口市人，汉族，1990年海南医学院毕业，副主任医师，主要从事骨伤、显微外科的诊治工作。 shuntian_zhang@126.com
  • 基金资助:

    课题受海南省自然科学基金项目(809046)资助，课题名称：中西医结合药物预防家兔髋部骨折后下肢深静脉血栓形成的实验研究。

Establishment of rabbit models of lower limb deep venous thrombosis after hip fracture

Zhang Ying, Jia Bing-shen, Zhou Jian-qiang, Tan Hai-tao, Wang Sheng, Fu Kun, Meng Zhi-bin   

  1. Department of Orthopedics, Affiliated Hospital of Hainan Medical College, Haikou   570102, Hainan Province, China
  • Received:2011-03-06 Revised:2011-06-08 Online:2011-07-09 Published:2011-07-09
  • Contact: Jia Bing-shen, Department of Orthopedics, Affiliated Hospital of Hainan Medical College, Haikou 570102, Hainan Province, China jbs123@163.com
  • About author:Zhang Ying, Associate chief physician, Department of Orthopedics, Affiliated Hospital of Hainan Medical College, Haikou 570102, Hainan Province, China shuntian_zhang@ 126.com
  • Supported by:

    the Natural Science Foundation of Hainan Province, No.809046*

PDF

306

被引次数

13

摘要：

背景：目前各种方法诱导下肢深静脉血栓的动物模型缺乏统一的标准。
目的：建立髋部骨折后下肢深静脉血栓形成兔模型。
方法：采用专用击打装置，用位于28 cm高度的击打物击打家兔后下肢左侧大腿根部；建立兔髋部骨折模型，另一侧兔后下肢不击打设为对照侧。4周后选取下肢髂静脉行彩色多普勒超声以及凝血功能的检查血栓形成情况。
结果与结论：家兔经打击后经彩色多普勒超声检查存在下肢深静脉血栓，血栓长度(124±37) mm。对照侧无下肢深静脉血栓形成。血栓形成率81.8%，死亡率为9.1%。结果证实，实验成功建立的兔髋部骨折后下肢深静脉血栓形成模型，简单可行。

关键词: 深静脉血栓形成, 肺栓塞, 髋, 骨折, 动物模型, 组织构建

Abstract:

BACKGROUND: At present, many methods for inducing lower limb venous thrombosis lack of unified standards.
OBJECTIVE: To establish rabbit models of lower limb venous thrombosis after hip facture
METHODS: Hip fracture was induced in rabbits by impacting the root of left leg by a dropping object from a height of 28 cm. The right leg was not impacted and served as the control side. After 4 weeks, the iliac and femoral veins of the lower limbs were selected for color Doppler ultrasonography and blood coagulation examination.
RESULTS AND CONCLUSION: Color Doppler ultrasonography showed that there was a thrombosis area with a length of (124±37) mm in the lower limb deep veins. No lower limb deep venous thrombosis was found in the control side. Thrombosis rate was 81.8% and death rate was 9.1%. These findings suggest that rabbit models of lower limb deep venous thrombosis after hip fracture could be successfully established, and the method is simple and feasible.

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