中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (26): 4876-4879.doi: 10.3969/j.issn.1673-8225.2011.26.032

• 骨与关节学术探讨 academic discussion of the bone and joint • 上一篇    下一篇

人工椎体的组织相容性和力学性能

梁晟伟1，黄民锋2，王向鹏3   

  1. 1天等人民医院骨科，广西壮族自治区崇左市   532800
    2广西中医学院附属瑞康医院骨科脊柱一区，广西壮族自治区南宁市   530011
    3广西中医学院，广西壮族自治区南宁市  530001
  • 收稿日期:2011-01-20 修回日期:2011-05-16 出版日期:2011-06-25 发布日期:2011-06-25
  • 通讯作者: 黄民锋，广西中医学院附属瑞康医院骨科脊柱一区，广西壮族自治区南宁市 530011 hmf7219@163.com
  • 作者简介:梁晟伟，男，1974年生，广西壮族自治区天等县人，壮族，1999年广西医科大学毕业，主治医师，主要从事骨外科(尤其脊柱外科)方面的研究。

Artificial vertebral histocompatibility and mechanical properties

Liang Sheng-wei1, Huang Min-feng2, Wang Xiang-peng3   

  1. 1Department of Orthopedics, Tiandeng People’s Hospital, Chongzuo  532800, Guangxi Zhuang Autonomous Region, China
    2Department of Orthopedics, Ruikang Hospital, Guangxi Traditional Chinese Medical University, Nanning  530011, Guangxi Zhuang Autonomous Region, China
    3Guangxi Traditional Chinese Medical University, Nanning  530001, Guangxi Zhuang Autonomous Region, China
  • Received:2011-01-20 Revised:2011-05-16 Online:2011-06-25 Published:2011-06-25
  • Contact: Huang Min-feng, Department of Orthopedics, Ruikang Hospital, Guangxi Traditional Chinese Medical University, Nanning 530011, Guangxi Zhuang Autonomous Region, China hmf7219@163.com
  • About author:Liang Sheng-wei, Attending physician, Department of Orthopedics, Tiandeng People’s Hospital, Chongzuo 532800, Guangxi Zhuang Autonomous Region, China hmf7219@163.com

PDF

357

被引次数

1

摘要：

背景：近年来，随着组织工程学的发展，椎体替代材料趋于多样化，学者们不再满足于其能否恢复椎体高度与即刻稳定性，而是更为关注远期的融合，良好的组织相容性和力学性能。
目的：分析国内人工椎体的组织相容性和力学性能。
方法：以“人工椎体、相容性、生物力学”为检索词在中国期刊全文数据库中检索与人工椎体生物相容性和生物力学研究相关的文献进行分析。
结果与结论：人工椎体组织相容性的动物实验显示，纳米羟基磷灰石/聚酰胺66复合人工椎体成分和结构与人体骨相似，具有良好的生物相容性，成骨活性；可发生生物降解，其降解作用与成骨能力匹配。人工椎体的生物力学研究显示出纳米羟基磷灰石/聚酰胺66复合人工椎体不仅具有良好的生物活性，而且具有良好的轴向压缩载荷和椎间支撑能力，力学性能优异。生物陶瓷人工椎体不仅具有良好的生物相容性，而且在治疗椎体肿瘤中有靶向定位作用；金属材料的人工椎体经过多年的改进，其生物相容性亦可满足临床要求。就各类型人工椎体优劣而言，仍需进一步大量研究和实践，就其临床应用而言，需根据临床需要进行选择。

关键词: 人工椎体, 生物相容性, 生物力学, 组织相容性, 植入体

Abstract:

BACKGROUND: Recently, with the development of tissue engineering, the substitutes of the vertebral body are various. Scholars focus on not only restoration of vertebral height and stability, but also long-term fusion effect, biocompatibility and mechanical properties.
OBJECTIVE: To analyze the histocompatibility and mechanical properties of artificial vertebral body.
METHODS: A retrieve of CNKI for articles about biocompatibility and mechanical properties of artificial vertebral body was performed using the keywords of “artificial vertebral body, compatibility, biomechanics”.
RESULTS AND CONCLUSION: The histocompatibility examination showed that nano-hydroxyapatite/polyamide 66 composites have similar composition and structure to human bone with good biocompatibility and osteogenic activity; can be biodegradable, and their degradation matches to osteogenic activity. The biomechanical studies demonstrated that nano-hydroxyapatite/polyamide 66 composites have good bioactivity, good axial compression load and excellent ability to branch out the intervertebral, meaning perfect mechanical properties. Bio-ceramic artificial vertebral body not only has good biocompatibility, but also plays a role in targeting location of vertebral tumors. After years of improvement, metal vertebral body can also meet the clinical requirements in biocompatibility. On the pros and cons of various types of artificial vertebral bodies, a large amount of studies and practices should be done, while in clinic, the selection of artificial vertebral body should be done according to the clinical need.

中图分类号: