中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (19): 3573-3576.doi: 10.3969/j.issn.1673-8225.2011.19.037

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞的相关迁移机制

徐世红1，谢兴文2   

  1. 1甘肃中医学院，甘肃省兰州市  730000
    2甘肃省中医院，甘肃省兰州市  730020
  • 收稿日期:2010-11-23 修回日期:2011-03-12 出版日期:2011-05-07 发布日期:2011-05-07
  • 通讯作者: 谢兴文，博士，副主任医师，甘肃省中医院，甘肃省兰州市 730020
  • 作者简介:徐世红★，男，1983年生，甘肃省兰州市人，汉族，甘肃中医学院在读硕士，主要从事中医药治疗骨关节疾病的研究。 xushihong2015@163.com
  • 基金资助:

    国家自然科学基金项目(81060299)。

Migration mechanism of bone marrow mesenchymal stem cells

Xu Shi-hong1, Xie Xing-wen2   

  1. 1Gansu College of Traditional Chinese Medicine, Lanzhou  730000, Gansu Province, China
    2Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou  730020, Gansu Province, China
  • Received:2010-11-23 Revised:2011-03-12 Online:2011-05-07 Published:2011-05-07
  • Contact: Xie Xing-wen, Doctor, Associate chief physician, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730020, Gansu Province, China
  • About author:Xu Shi-hong★, Studying for master’s degree, Gansu College of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China xushihong2015@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81060299*

PDF

391

被引次数

13

摘要：

背景：基于骨髓间充质干细胞的多向分化潜能，促使其迁移至损伤部位，可对患者的康复起到极大的促进作用。
目的：通过国内外相关文献的综合分析，探讨细胞因子和炎症因子促进骨髓间充质干细胞迁移的作用机制。
方法：由第一作者应用计算机检索CNKI、Pubmed相关文献，英文检索词“BMSCs，chemotactic factor，migration”，中文检索词为“骨髓间充质干细胞，细胞因子，迁移”，排除重复性研究，计算机初检到68篇文献，最终保留23篇进行归纳总结。
结果与结论：骨髓间充质干细胞具有强大的分化潜能，在临床疾病治疗中起到了巨大的辅助作用，同时鉴于该细胞取材简单、方便，易于体外培养，所以就其增殖、分化、迁移的研究实属国内外热点。相关细胞因子的干预，促使骨髓间充质干细胞的迁移加强，这就使得细胞因子对该细胞的促迁移研究极具价值。

关键词: 迁移, 骨髓间充质干细胞, 细胞因子, 中药, 综述文献

Abstract:

BACKGROUND: Based on the multiple differentiation potential, bone marrow mesenchymal stem cells (BMSCs) migrating to the injury site greatly promote patient’s rehabilitation.
OBJECTIVE: To investigate the mechanism of cytokines and inflammatory factors to promote the migration of BMSCs based on analysis of related literature.
METHODS: The first author retrieved China National knowledge Infrastructure and PubMed datebases for concering articles .The key words were “BMSCs, chemotactic factor, migration” in Chinese and English. A total of 68 articles were retrieved primarily by computer, and 23 articles were finally included for review according to inclusion criteria. 
RESULTS AND CONCLUSION: BMSCs have a strong differentiation potential and play a huge assistance role in the clinical treatment. At the same time, because BMSCs are easy and simple to harvest and culture in vitro, studies concerning the proliferation, differentiation and migration of BMSCs are hot points. The intervention function of related cell factors urges BMSCs to strength migration.

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