中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (18): 3391-3394.doi: 10.3969/j.issn.1673-8225.2011.18.039

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

异种肌腱移植免疫反应的处理方法

高春光，林月秋   

  1. 昆明医学院昆明总医院临床医院，解放军成都军区昆明总医院全军骨科中心，云南省昆明市650032
  • 收稿日期:2010-11-01 修回日期:2011-03-10 出版日期:2011-04-30 发布日期:2011-04-30
  • 通讯作者: 林月秋，教授，主任医师，解放军昆明总医院附属骨科医院成都军区昆明总医院全军骨科中心，云南省昆明市 650032 lyqkm43@163.com
  • 作者简介:高春光★，男，1982年生，河北省衡水市人，汉族，昆明医学院在读硕士，医师，主要从事骨外科方面的研究。 gcg82@126.com
  • 基金资助:

    成都军区科研项目立项编号(MB07028)。

Immune response treatments after heterogeneous tendon transplantation

Gao Chun-guang, Lin Yue-qiu   

  1. Orthopaedic Center of PLA, Kunming General Hospital of Chengdu Military Command, Kunming 650032, Yunnan Province, China
  • Received:2010-11-01 Revised:2011-03-10 Online:2011-04-30 Published:2011-04-30
  • Contact: Lin Yue-qiu, Professor, Chief physician, Orthopaedic Center of PLA, Kunming General Hospital of Chengdu Military Command, Kunming 650032, Yunnan Province, China lyqkm43@163.com
  • About author:Gao Chun-guang★, Studying for master’s degree, Physician, Orthopaedic Center of PLA, Kunming General Hospital of Chengdu Military Command, Kunming 650032, Yunnan Province, China gcg82@126.com
  • Supported by:

    the Saence and Technology Program of Chengdu Military Area Command, No. MB07028*

PDF

307

被引次数

4

摘要：

背景：异体肌腱移植是目前修复肌腱缺损的理想方法。其中异种肌腱供源丰富，但移植后的排斥反应为其使用受到限制的主要原因。
目的：对异种肌腱的抗原性和移植后的免疫反应及降低异种肌腱排斥反应的方法的研究进展进行综述。
方法：第一作者应用计算机检索PubMed数据库和CNKI数据库中1995-01/2010-12在标题和摘要中以“肌腱，异体移植，免疫”或“tendons，transplantation Immunity，”为检索词进行检索。选择文章内容与肌腱移植免疫反应相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到196篇文献，根据纳入标准选择30篇文章进行综述。
结果与结论：目前对异种移植物抗原的研究包括半乳糖-a-1，3-半乳糖抗原(Gal)和非Gal抗原，以对Gal抗原基因研究的较多。Gal抗原由存在于哺乳动物细胞表面的Gal-a-1，3-Gal抗原引起，是引起超级排斥反应的主要因素。异种肌腱移植后早期以细胞免疫为主，晚期仅有体液免疫参与；动物实验表明经不同物理和化学方法处理后的异种肌腱有潜在应用价值。肌腱移植不同于器官移植，肌腱移植属于非功能性移植，异体肌腱只为受区提供一个生长支架，移植后的生物学特点主要体现在生物力学上，因此，探讨出新的消除免疫原性同时保留移植物生物力学特性的方法是异种肌腱移植获得突破的关键。

关键词: 肌腱, 异体移植, 免疫排斥反应, 处理方法, 研究现状

Abstract:

BACKGROUND: Tendon defects or damaged when clinically repairing needed transplant tendons. Heterogeneous tendon is an ideal method to repair the tendon defects. Heterogeneous tendon source is sufficient, but post-transplantation rejection limits the use of heterogeneous tendons.
OBJECTIVE: To review the antigens of heterogeneous tendons and post-transplantation immune response as well as reduction of xenograft rejection.
METHODS: Using “tendons, transplantation, immunity” in Chinese and English as the key words, the first author conducted a computer search of Pubmed database (http://www/ncbi.nlm.nih.gov/PubMed) and CNKI database (www.cnki.net/index.htm) through screening the titles and abstracts. Articles recently published or published in the authority magazines were preferred in the same field. Totally 30 documents were included.
RESULTS AND CONCLUSION: At present, the study for heterogeneous graft antigens involves Gal-a-1, 3-Gal antigen (Gal) and non-Gal antigen, especially Gal antigen gene. Gal antigen is a main factor of super rejection (HAR). Cellular immunity mainly exists at early stage after heterogeneous tendon transplantation, and only humoral immunity exists at late stage. Animal experiments have shown that heterogeneous tendons after different physical and chemical treatments have potential application value. Unlike other organ transplantation, tendon transplantation is a non-functional transplantation, which only provides a growth support for the recipient. The biological research after transplantation mainly focuses on bio-mechanical characteristics. Therefore, the elimination of the immunogenicity and reservation of graft biomechanical properties is the key to heterogeneous tendon graft.

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