中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (18): 3387-3390.doi: 10.3969/j.issn.1673-8225.2011.18.038

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

冷冻保存异体软骨移植免疫排斥反应的研究状况

吴雅迪1，张  刚2   

  1. 1泰山医学院运动医学研究所，山东省泰安市271000
    2泰山医学院附属医院骨三科，山东省泰安市  271000
  • 收稿日期:2011-02-15 修回日期:2011-03-15 出版日期:2011-04-30 发布日期:2011-04-30
  • 作者简介:吴雅迪★，女，1982年生，山东省泰安市人，汉族，2009年泰山医学院毕业，硕士，助教，主要从事运动康复方面研究。 kuaile-320@163.com

Immunological rejection reaction and cryopreserved cartilage allograft 

Wu Ya-di1, Zhang Gang2   

  1. 1Sports Medicine Institute, Taishan Medical College, Taian  271000, Shandong Province, China
    2Third Department of Orthopedics, Affiliated Hospital of TaiShan Medical College, Taian 271000, Shandong Provice，China
  • Received:2011-02-15 Revised:2011-03-15 Online:2011-04-30 Published:2011-04-30
  • About author:Wu Ya-di★, Master, Teaching assistant, Sports Medicine Institute, Taishan Medical College, Taian 271000, Shandong Province, China kuaile-320@163.com

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403

被引次数

7

摘要：

背景：目前多采用冷冻保存方法来降低异体软骨移植免疫排斥反应，但有关异体软骨的取材、冷冻保存方法、冷冻保存条件仍然需要深入的研究探讨。
目的：对于冷冻保存异体软骨移植后免疫排斥反应机制的研究进行回顾分析，并对不同保存方法的特点进行比较分析。
方法：由第一作者检索1990/2008 PubMed数据及万方数据库有关异体软骨移植后免疫排斥反应及冷冻保存方法对软骨移植影响等方面的相关文献。
结果与结论：异体软骨组织移植治疗关节软骨缺损治疗效果明显优于其他治疗方法。冷冻保存异体关节软骨保持了软骨组织的性状和生物学活性，而且可择期完成关节重建，并且有充裕的时间完成多项指标检测，防止供体携带细菌病毒和传染性疾病的传播，并且降低了软骨组织的抗原性，具有较大的临床应用价值。但冷冻保存的各个环节，如:低温保护剂的应用、降温和复温速度等方面还存在诸多问题，软骨移植后仍然会出现软骨吸收、退变等现象。随着冷冻生物学的不断进步，冷冻损伤机制的不断揭示，这些问题终将会解决，软骨组织冷冻保存技术会得到进一步的完善。

关键词: 软骨移植, 冷冻保存, 免疫原性, 免疫排斥, 异体软骨

Abstract:

BACKGROUND: At present, cryopreserved method is used to reduce immunological rejection after cartilage allograft transplantation, but allograft source, cryopreservation method, and frozen storage conditions still need in-depth studies.
OBJECTIVE: To retrospectively analyze the action mechanism related to immunological rejection reaction following transplantation of cryopreserved cartilage allograft, and to compare the characteristics of different preservation methods.
METHODS: The search by the first author was performed to retrieve PubMed and Wanfang databases for articles about immunological rejection following transplantation of cryopreserved cartilage allograft and cryopreservation effects on cartilage transplantation published 1990 to 2008.
RESULTS AND CONCLUSION: Cartilage allograft transplantation is better than other treatments for patients with articular cartilage defects. The cryopreservation method maintains the properties and biological activity of cartilage tissues, and based on this method, we can choose date for joint reconstruction and have plenty of time to complete the detection of a number of indicators so as to prevent the spread of bacteria, viruses and infectious diseases carried by the donor, and to reduce the antigenicity of cartilage tissue, with great clinical value. However, in all aspects of cryopreservation, such as, the application of cryoprotectant, cooling and rewarming speed, there are still many problems. And after cartilage transplantation, there is occurrence of cartilage resorption, degeneration and so on. With the development of frozen biology and revealing of frozen injury mechanism, these problems will be met, cartilage cryopreservation technology will be further improved.

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