中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (36): 6825-6827.doi: 10.3969/j.issn.1673-8225.2010.36.040

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

许旺细胞在周围神经损伤修复中的作用及其可能分子机制

高  伟，邵水金，胡琳娜，刘延祥   

  1. 上海中医药大学，上海市 201203
  • 出版日期:2010-09-03 发布日期:2010-09-03
  • 通讯作者: 邵水金，博士，教授，上海中医药大学，上海市 201203
  • 作者简介: 高伟★，女，1984年生，山东省郓城县人，汉族，上海中医药大学在读硕士，主要从事电针对许旺细胞增殖机制的研究。gaowei529982@yahoo.com.cn
  • 基金资助:

    上海市教育委员会重点学科建设项目(J50301)；上海中医药大学名师传承研究工程第二阶段建设项目。

Effects and possible molecular mechanisms of Schwann cells for the repair of peripheral nerve damage   

Gao Wei, Shao Shui-jin, Hu Lin-na, Liu Yan-xiang   

  1. Shanghai University of Traditional Chinese Medicine, Shanghai  201203, China
  • Online:2010-09-03 Published:2010-09-03
  • Contact: Shao Shui-jin, Doctor, Professor, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • About author:Gao Wei★, Studying for master’s degree, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China gaowei529982@ yahoo.com.cn
  • Supported by:

     the Key Subject Construction Program of Education Committee of Shanghai City, No. J50301*; the Second Phase Construction Program of Great Master Lineage Research Engineering of Shanghai University of Traditional Chinese Medicine*

PDF

733

被引次数

27

摘要：

背景：周围神经损伤后神经功能的恢复一直是人们关注的焦点。许旺细胞在促神经功能恢复方面有着不可替代的作用。
目的：对国内外有关许旺细胞在促神经功能恢复方面的作用及其可能的分子机制作一综述。
方法：应用计算机检索CNKI、VIP和OVID数据库中1993-01/2010-01关于周围神经损伤的文章，在标题和摘要中以“许旺细胞，周围神经，神经再生，综述”或“Schwann Cells，Peripheral Nerve，Nerve Regeneration, Review”为检索词进行检索。选择文章内容与许旺细胞对周围神经损伤的作用有关者，同一领域文献则选择近期发表或发表在权威杂志上的文章。初检得到256篇文献，根据纳入标准选择关于许旺细胞作用机制的24篇文献进行综述。
结果与结论：许旺细胞通过多种途径作用于受损的周围神经，进而促进损伤神经功能的恢复。如何促使损伤局部许旺细胞更多的增殖将成为更好地促进损伤神经功能恢复的一大突破点。综合各方面因素，电针治疗周围神经损伤将有更好的前景。

关键词: 许旺细胞, 周围神经, 神经再生, 电针, 综述文献

Abstract:

BACKGROUND: The recovery of neural function following peripheral nerve damage has been the focus. Schwann cells have very important effects on the recovery of neural function.
OBJECTIVE: To summarize the effect and possible molecular mechanism of Schwann cells in promoting neural function recovery.
METHODS: The databases of China National Knowledge Infrastructure, VIP and Offshore Vessel Inspection Database were searched for articles about peripheral nerve damage published from January 1993 to January 2010. The key words were “Schwann cells, peripheral nerve, nerve regeneration and review”, which were searched by inputting in titles and abstracts. The articles addressing Schwann cells effects on peripheral nerve damage were selected. The literatures in the same field that published recently or in authorized journals were included. There were 256 articles after the initial survey. Finally, 24 articles concerning action mechanism of Schwann cells according to inclusion criteria were included for this review. 
RESULTS AND CONCLUSION: Schwann cells affect the damaged peripheral nerve through various channels and promote poor functional recovery. How to accelerate proliferation of Schwann cells will be a breakthrough point for the recovery of neural function. By synthesizing various factors, electroacupuncture for peripheral nerve injury will have a better future.

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