中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (34): 6409-6412.doi: 10.3969/j.issn.1673-8225.2010.34.034

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

心血管支架材料生物力学及生物相容性与置入后血管再狭窄

王雪芳1，刘艳明2   

  1. 1河北北方学院，河北省张家口市  075000；2解放军251医院心内二科，河北省张家口市  075000
  • 出版日期:2010-08-20 发布日期:2010-08-20
  • 通讯作者: 刘艳明，硕士，副主任医师，解放军251医院心内二科，河北省张家口市 075000
  • 作者简介:王雪芳★，女，1978年生，北京市人，汉族，2002年河北北方学院医学院毕业，硕士，讲师，主要从事心血管生理的研究。 wxfang_2003@yahoo.com.cn

Biomechanics and biocompatibility of cardiovascular scaffolds as well as vascular restenosis after implantation

Wang Xue-fang1, Liu Yan-ming2   

  1. 1 Hebei North University, Zhangjiakou   075000, Hebei Province, China; 2 Second Department of Cardiology, The 251 Hospital of Chinese PLA, Zhangjiakou   075000, Hebei Province, China
  • Online:2010-08-20 Published:2010-08-20
  • Contact: Liu Yan-ming, Master, Associate chief physician, Second Department of Cardiology, The 251 Hospital of Chinese PLA, Zhangjiakou 075000, Hebei Province, China
  • About author:Wang Xue-fang★, Master, Lecturer, Hebei North University, Zhangjiakou 075000, Hebei Province, China wxfang_2003@yahoo.com.cn

PDF

809

被引次数

20

摘要：

目的：对心血管支架材料生物力学、生物相容性与置入后血管再狭窄进行归纳总结。
方法：第一作者应用计算机检索PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及CNKI数据库(www.cnki.net/ index.htm)，在标题和摘要中以“生物力学，生物相容性，置入后血管再狭窄”或“biomechanics，biocompatibility，in-stent restenosi”为检索词进行检索。选择文章与检索关键词材料学特点、生物相容性及其应用效果相关，同一领域文献则选择近期发表或发表在权威杂志文章。共纳入24篇文献。
结果：一个理想的心血管支架应具备良好的生物相容性、合适的扩张比、足够的柔韧性和顺应性、材料易消毒、微环境易控制性等等，置入后必须保证能让细胞很好的贴附生长，具有良好的细胞亲和性。目前支架置入后血管再狭窄的确切发生机制尚不明确，减小置入后血管再狭窄的发生率就显得日益紧迫，置入后血管再狭窄除了与支架本身的抗腐蚀性，杨氏模量，屈服强度，材料柔顺性等生物力学有关外，还与置入后炎症反应、内皮细胞增殖、纤维组织细胞增生等生物相容性有关。
结论：选择优秀的支架除了必须高度满足可靠合适的扩张性、优效的可视性和微环境易控性等，还应具有良好的材料生物力学性及生物相容性，就目前来看生物可降解支架有着极优秀的开选择优秀的支架除了必须高度满足可靠合适的扩张性、优效的可视性和微环境易控性等，还应具有良好的材料生物力学性及生物相容性，就目前来看生物可降解支架有着极优秀的开发潜能。

关键词: 心血管支架, 生物力学, 生物相容性, 置入, 生物材料

Abstract:

OBJECTIVE: To summarize the biomechanics and biocompatibility of cardiovascular scaffold materials, as well as vascular restenosis after implantation.
METHODS: The first author conducted a computer search of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI database (www.cnki.net/index.htm), with key words of “biological mechanical, biocompatibility, in-stent restenosis” in English and Chinese in title and abstracts. Articles related to material science, biocompatibility and application were selected, those recently published or published in the authority journal were preferred in the same field. Totally 24 literatures were included.
RESULTS: An ideal cardiovascular stent should have good biocompatibility, appropriate expansion ratio, sufficient flexibility and compliance, be easy to disinfect, easily controlled micro-environment. Cells must be ensured to adhere and grow after implantation, with good affinity. Currently, the mechanism underlying restenosis after stenting remains unclear, it becomes increasingly urgent to reduce the incidence of restenosis after implantation. In addition to corrosion resistance, Young’s modulus, yield strength and material compliance, the restenosis after implantation is also related to the inflammatory response after implantation, endothelial cell proliferation, cell hyperplasia of fibrous tissue and other biocompatibilities.
CONCLUSION: The excellent scaffold should have not only reliable and suitable expanding features, excellent visibility and effective controlled micro-environment, but also good biomechanical properties and biocompatibility. At present, biological biodegradable stent has a very good development potential.

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