中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (33): 6198-6201.doi: 10.3969/j.issn.1673-8225.2010.33.029

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

生长因子参与应力作用下骨重建

王  力，赵文志，李  斌，苏  晋   

  1. 大连医科大学第二临床学院骨科，辽宁省大连市 116027
  • 出版日期:2010-08-13 发布日期:2010-08-13
  • 通讯作者: 赵文志，博士，教授，硕士生导师，大连医科大学第二临床学院骨科，辽宁省大连市 116027 drzwz@163.com
  • 作者简介:王力★，男，1985年生，河北省邯郸市人，汉族，大连医科大学在读硕士，主要从事生物力学、骨科学方面的研究。 juhongshan@yahoo.cn
  • 基金资助:

    国家自然科学基金项目(批准号：30970708)，课题名称：低频振动刺激BMSCs修复骨缺损生物模型研究。

Growth factor participates in bone reconstruction under stress

Wang Li, Zhao Wen-zhi, Li Bin, Su Jin   

  1. Department of Orthopedics, Second Affiliated Hospital of Dalian Medical University, Dalian  116023, Liaoning Province, China
  • Online:2010-08-13 Published:2010-08-13
  • Contact: Zhao Wen-zhi, Doctor, Professor, Master’s supervisor, Department of Orthopedics, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China drzwz@163.com
  • About author:Wang Li★, Studying for master’s degree, Department of Orthopedics, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China juhongshan@yahoo.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30970708*

PDF

628

被引次数

15

摘要：

背景：生长过程中与成熟后的骨骼在应力的作用下可以不断地重新塑造其形状、重建其骨质。不同的生长因子参与调节应力下骨重建过程。
目的：了解生长因子在应力影响骨重建中的产生与表达的作用。
方法：电子检索PubMed数据库1970-01/2009-12、中国知识资源总库(CNKI)1990-01/2009-12和中国生物医学文献数据库(CBM)1990-01/2009-12收录的骨重建应力作用生长因子的相关综述和论文报告，并分析其生长因子对于骨重建的研究进展。
结果与结论：共纳入生长因子对于骨重建相关文献28篇。应力可在骨骼局部产生剪应力，骨细胞等可感受剪应力并做出反应，生成骨形态发生蛋白、前列腺素E2、胰岛素样生长因子1等信号分子，通过旁分泌、自分泌以及其他信号传导效应，实现骨骼的重建。但是目前人们对应力作用细胞的传递机制还不太清楚，对应力与骨生长重建关系的力学与生物化学之间的相互作用还不明确。

关键词: 应力, 骨重建, 生长因子, 骨形态发生蛋白, RANKL/RANK/OPG骨调节轴, 骨组织工程

Abstract:

BACKGROUND: Skeleton can remodel its shapes and rebuild sclerotin in the process of growth or mature. Various growth factors involve in this procedure under stress.
OBJECTIVE: To explore the produce and expression of growth factor in bone reconstruction under stress.
METHODS: Databases of PubMed (1970-01/2009-12), CNKI and CBM (1990-01/2009-12) were retrieved by computer to search documents with regard to growth factor participation in bone reconstruction under stress, and the effects of growth factor on bone reconstruction were analyzed.
RESULTS AND CONCLUSION: Totally 28 papers were included. The environment of the stress can prompted the proliferation of cells, induce the rearrangement of cytoskeleton and the change of cellular shape, accelerate the mineralization of cell matrix, boost the release of cytokine and bone hormones (bone morphogenetic protein, prostaglandin E2, as well as insulin-like growth factor 1), then to control the metabolism of bone, to stimulate the growth and the remodeling of bone. However, the transfer mechanism of stress on cells is unclearly, and the interactions between stress and remodeling adaptation of bone remains poorly understood.

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