中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (28): 5177-5180.doi: 10.3969/j.issn.1673-8225.2010.28.011

• 组织构建循证医学 evidence-based medicine in tissue construction • 上一篇    下一篇

补充维生素E能否降低前列腺癌患病风险的荟萃分析

李  嘉，侯  智   

  1. 青海大学附属医院泌尿外科，青海省西宁市 810000
  • 出版日期:2010-07-09 发布日期:2010-07-09
  • 通讯作者: 侯智，副主任医师，青海大学附属医院泌尿外科，青海省西宁市 810000 lijiahouzhi@163.com
  • 作者简介:李 嘉，男，1976年生，青海省西宁市人，土族，1999年青海大学医学院毕业，主治医师，主要从事泌尿系肿瘤综合治疗的研究。

Whether vitamin E supplements can decrease the risk of prostate cancer: Meta analysis

Li Jia, Hou Zhi   

  1. Department of Urinary Surgery, Affiliated Hospital of Qinghai University, Xining  810000, Qinghai Province, China
  • Online:2010-07-09 Published:2010-07-09
  • Contact: Hou Zhi, Associate chief physician, Department of Urinary Surgery, Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China lijiahouzhi@163.com
  • About author:Li Jia, Attending physician, Department of Urinary Surgery, Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China

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摘要：

背景：补充维生素E是否能降低前列腺癌的患病风险尚无定论。
目的：用荟萃分析的方法定量评价补充维生素E与前列腺癌患病风险之间的关系。
方法：计算机检索PubMed、EMBASE、Cochrane Library、CBM、CNKI、VIP数据库，手工检索相关领域的杂志，同时从纳入文献的参考文献中全面搜集有关补充维生素E对前列腺癌影响的随机对照试验，用RevMan5.0软件进行统计分析。
结果与结论：纳入5篇随机对照试验共计85 549人，Meta分析结果显示：补充维生素与安慰剂相比对前列腺癌发病率的影响差异均无显著性意义(RR=0.96，95%CI为0.85~1.08)，且对前列腺癌病死率的影响差异也无显著性意义(RR=0.84，95%CI为0.57~1.24)。表明补充维生素E并不能降低前列腺癌的发病率和病死率，但上述结果仍需高质量大样本的随机对照试验进一步证实。

关键词: 维生素E, 前列腺癌, 荟萃分析, 发病率, 病死率

Abstract:

BACKGROUND: It is poorly understood whether vitamin E supplements can decrease the risk of prostate cancer.
OBJECTIVE: To explore the relationship between vitamin E supplements and the risk of prostate cancer by Meta analysis.
METHODS: PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database, CNKI, VIP and bibliographies were retrieved to search articles containing randomized controlled trials of vitamin E supplements on risk of prostate cancer, and the data were analyzed by using RevMan5.0.
RESULTS AND CONCLUSION: A total of 5 randomized controlled trials containing 85 549 participants were included. The result of Meta analysis showed that, compared to placebo, the vitamin E supplements did not significantly affect the incidence of prostate cancer [RR=0.96, 95%CI (0.85-1.08)] and mortality [RR=0.84, 95%CI (0.57-1.24)]. Vitamin E supplements could not reduce the incidence of prostate cancer and mortality, the results still need to be confirmed by high quality, and large sample size randomized controlled trials.

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