中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (25): 4611-4613.doi: 10.3969/j.issn.1673-8225.2010.25.013

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

Ti6Al4V-AlTiN涂层材料的急性毒性试验

朱维东1，朱  涛1，王旭东2，蒋耀光3   

  1. 1贵州大学材料与冶金学院，贵州省材料结构与强度重点实验室，贵州省贵阳市 550003；2贵阳医学院生理学部，贵州省贵阳市 550004；3解放军第三军医大学大坪医院，重庆市 400042
  • 出版日期:2010-06-18 发布日期:2010-06-18
  • 作者简介:朱维东，男，1954年生，重庆市人，汉族，1982年原贵州工学院毕业，教授，近年来主要从事材料表面改性及生物学性能研究。 wdzhu@263.net
  • 基金资助:

    贵州省科技项目(20082004)。

Acute toxicity test of Ti6Al4V-AlTiN coating materials

Zhu Wei-dong1, Zhu Tao1, Wang Xu-dong2, Jiang Yao-guang3   

  1. 1 College of Materials and Metallurgy, Guizhou University, Guizhou Provincial Key Laboratory for Structure of Materials and Mechanical Behavior, Guiyang   550003, Guizhou Province, China; 2 Department of Physiology, Guiyang Medical University, Guiyang   550004, Guizhou Province, China; 3 Daping Hospital, Third Military Medical University of Chinese PLA, Chongqing   400042, China
  • Online:2010-06-18 Published:2010-06-18
  • About author:Zhu Wei-dong, Professor, College of Materials and Metallurgy, Guizhou University, Guizhou Provincial Key Laboratory for Structure of Materials and Mechanical Behavior, Guiyang 550003, Guizhou Province, China wdzhu@263.net
  • Supported by:

    Guizhou Provincial Science and Technology Project, No. 20082004*

PDF

449

被引次数

4

摘要：

背景：AlTiN陶瓷涂层具有高硬度、优良的摩擦磨损性能、良好的化学惰性和附着力强的特点，非常符合生物陶瓷的特征。为能够进入临床安全使用，需全面评价AlTiN涂层的急性毒性。
目的：对Ti6Al4V-AlTiN涂层材料进行急性毒性试验研究，为长期毒性试验和其他毒理学试验提供参考依据。
方法：将小鼠左右两侧股四头肌内无菌操作一次注入受试样品Ti6Al4V-AlTiN涂层材料，观察注入受试样品后14 d动物全身情况及注射局部反应情况，试验中设置生理盐水作为阴性对照。
结果与结论：小鼠两侧股四头肌内一次注射受试样品，观察14 d后，受试样品各组动物体质量增长与阴性对照组差异无显著性意义。饮食、外观、分泌物、排泄物、呼吸、中枢神经系统及四肢活动无异常、注射局部无充血、红肿、无动物死亡情况及中毒现象。

关键词: 急性毒性试验, AlTiN涂层, Ti6Al4V合金, 高度离子化脉冲工艺, 小鼠

Abstract:

BACKGROUND: AlTiN ceramic coatings have many advantages such as high hardness, excellent wear properties, good chemical inertness and strong adhesion, which are all consistent with the characteristics of bio-ceramics. To achieve the clinical safety, a comprehensive evaluation of acute toxicity AlTiN coating is needed.
OBJECTIVE: To test acute toxicity of Ti6Al4V-AlTiN coating materials, and to provide a reference for long-term toxicity and other toxicological tests.
METHODS: The mouse left and right femoral quadriceps muscle was injected with aseptic Ti6Al4V-AlTiN coating material, the general condition and reaction on the injection site of animals were observed at 14 days after injection, normal saline served as the negative control.
RESULTS AND CONCLUSION: At 14 days after Ti6AI4V-AITiN injection into mouse quadriceps muscle on both sides, there was no significant difference in body mass growth between test sample group and negative control group. The animals showed normal diet, appearance, secretions, excretions, respiratory condition, central nervous system and limb activities, with no local congestion or swelling in the injection site, no animals died or showed poisoning.

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