中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (24): 4512-4515.doi: 10.3969/j.issn.1673-8225.2010.24.033

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

衰老骨骼肌中的兴奋-收缩偶联与MG29蛋白

瞿惠芳1，潘文朝2，闫万军3   

  1. 1南京艺术学院体育教研室，江苏省南京市  210000；2廊坊职业技术学院，河北省廊坊市  102800；3河北师范大学体育学院，河北省石家庄市  050016
  • 出版日期:2010-06-11 发布日期:2010-06-11
  • 通讯作者: 闫万军，博士，研究员，硕士生导师，河北师范大学体育学院，河北省石家庄市050016 wjyan@yahoo.cn
  • 作者简介:瞿惠芳，女，1961年生，江苏省南京市人，汉族，1982年扬州大学体育学院毕业，副教授，主要从事运动健康促进方向的研究。 quhuifang@yahoo.cn
  • 基金资助:

    课题得到河北省教育厅自然科学研究项目资助，项目编号：Z2009129。

Effects of MG29 protein on excitation-contraction coupling in senescent muscles 

Qu Hui-fang1, Pan Wen-zhao2, Yan Wan-jun3   

  1. 1 Department of Physical Education, Nanjing College of Fine Arts, Nanjing  210000, Jiangsu Province, China; 2 Langfang Vocational College, Langfang  102800, Hebei Province, China; 3 College of Sports Science, Hebei Normal University, Shijiazhuang  050016, Hebei Province, China
  • Online:2010-06-11 Published:2010-06-11
  • Contact: Yan Wan-jun, Doctor, Researcher, Master’s supervisor, College of Sports Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, China wjyan@yahoo.cn
  • About author:Qu Hui-fang, Associate professor, Department of Physical Education, Nanjing College of Fine Arts, Nanjing 210000, Jiangsu Province, China quhuifang@yahoo.cn
  • Supported by:

    the Natural Science Foundation of Education Department of Hebei Province, No. Z2009129*

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摘要：

背景：“兴奋-收缩偶联”是神经-肌肉功能的基本功能特点，在衰老过程中肌肉功能的衰退与肌细胞中的兴奋-收缩解偶联存在密切关系。近年来针对衰老肌细胞功能退化的研究有了许多新进展。
目的：综述有关衰老肌细胞钙离子变化的机制以及MG29蛋白在钙离子及与兴奋-收缩偶联过程中的作用的有关文献，为进一步了解衰老骨骼肌功能退化的机制提供理论参考。
方法：应用计算机检索CNKI 期刊全文数据库(2000-01/2009-11)和PubMed数据库(2009-01/2009-12)与衰老肌细胞钙离子变化的机制以及MG29蛋白及兴奋-收缩偶联相关的文献，检索词分别为“兴奋-收缩偶联；肌组织；肌细胞；衰老；抗阻训练；MG29”和“excitation-contraction；muscle；muscle cell；senescence；resistance training；MG29”。纳入和衰老肌细胞钙离子、兴奋-收缩偶联及MG29蛋白相关的研究，排除陈旧的、重复的以及缺乏可信度的文献。
结果与结论：初步检索到中英文文献共43篇，根据本研究的纳入排除标准，排除9篇不符合标准的文献，最终纳入34篇文献进行分析。结果发现，许多研究已经证明MG29蛋白在肌细胞兴奋-收缩偶联中起着重要的作用，而随增龄MG29会出现明显减少的规律，推断其在肌组织衰老中可能扮演重要角色。更为重要的是，新近有研究者发现适宜的抗阻训练可以使肌组织中MG29表达量增加。

关键词: 兴奋-收缩偶联, 肌组织, 肌细胞, MG29, 抗阻训练, 衰老

Abstract:

BACKGROUND: Excitation-contraction coupling is a basic functional feature of nerve-muscle, to some extent, which closely associates with functional deterioration of senescent muscles. Researchers have made obviously progress in this field recently.
OBJECTIVE: To summarize the mechanism of the change of Ca2+ in senescent muscle cells and the effects of MG29 protein on Ca2+ changes and excitation-contraction coupling, and to provide reference for studying functional deterioration via reviewing related literatures. 
METHODS: Papers related to mechanism of the change of Ca2+ in senescent muscle cells and correlation between MG29 protein and excitation-contraction coupling published in CNKI (2000-01/2009-11) in Chinese and in PubMed (2009-01/2009-12) in English were searched by computer based on the keywords of “excitation-contraction, muscle, muscle cell, senescence, resistance training and MG29”. Obsolete, repetitive and credibility-lacking literatures were excluded.
RESULTS AND CONCLUSION: Totally 43 papers were retrieved. According to the inclusive and exclusive criteria, 9 papers were excluded and 34 documents were included in the final analysis. The results showed that MG29 plays an important function in excitation-contraction coupling and decreases with age increasing. Therefore, MG29 is speculated as a key factor of muscle senescence. Importantly, recent researches show that MG29 could be increased by resistance training.

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