中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (15): 2792-2796.doi: 10.3969/j.issn.1673-8225.2010.15.032

• 组织构建综述 tissue construction review • 上一篇    下一篇

骨形态发生蛋白2和成纤维细胞生长因子2在骨组织工程中的应用

王  辉，刘思景，郭伟韬   

  1. 广东医学院附属医院骨科，广东省湛江市  524001
  • 出版日期:2010-04-09 发布日期:2010-04-09
  • 通讯作者: 郭伟韬，博士，副主任医师，广东医学院附属医院骨科，广东省湛江市 524001 guoweitao2000@sina.com
  • 作者简介:王 辉★，男，1972年生，河南省光山县人，汉族，广东医学院在读硕士，主治医师，主要从事骨科临床床及相关基础研究。 Wanghui668@yahoo.cn

Application of bone morphogenetic protein-2 and fibroblast growth factor-2 in bone tissue engineering 

Wang Hui, Liu Si-jing, Guo Wei-tao   

  1. Department of Orthopaedics, Affiliated Hospital of Guangdong Medical College, Zhanjiang  524001, Guangdong Province, China
  • Online:2010-04-09 Published:2010-04-09
  • Contact: to: Guo Wei-tao, Doctor, Associate chief physician, Department of Orthopaedics, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China guoweitao2000@sina.com
  • About author:Wang Hui★, Studying for master’s degree, Department of Orthopaedics, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China Wanghui668@yahoo.cn

PDF

400

被引次数

15

摘要：

背景：1995年Crane GM系统提出了骨组织工程的概念、研究方法、研究现状及发展前景后，骨组织工程日益成为学者们研究的重点。
目的：通过对1995年以来骨组织工程研究的进展的检索，探寻BMP-2和FGF-2在骨组织工程研究中的应用价值。
方法：以“bone tissue engineering，BMP，FGF， cytokine”为检索词，应用计算机检索中国知网和pubmed数据库相关文章，排除重复性研究，保留36篇文章做进一步分析。
结果与结论：骨组织工程的研究主要包括3个方面的内容：①种子细胞。②能引导组织再生的生物活性因子。③能够支持细胞黏附、增殖和分化以及释放生物活性因子的支架材料。细胞因子在骨组织工程中也拥有着不容忽视的重要地位，主要有有骨形态发生蛋白、骨转化生长因子、血管内皮生长因子、成纤维细胞生长因子，胰岛素样生长因子、血小板衍生生长因子等。其中骨形态发生蛋白2和成纤维细胞生长因子2在骨组织工程领域中应用最为广泛。

关键词: 骨, 组织工程, 骨形态发生蛋白, 成纤维细胞生长因子, 细胞因子, 文献综述

Abstract:

BACKGROUND: Bone tissue engineering becomes a research focus since its conception, method, condition and perspective was proposed systematically by Crane GM in 1995.    
OBJECTIVE: To seek the value of bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2) in bone tissue engineering research through retrieving the advanced of bone tissue engineering from 1995.
METHODS: Articles published in CNKI and Pubmed databases were searched by computer with key words of “bone tissue engineering, BMP, FGF, and cytokine”. According to inclusive and exclusive criteria, 36 documents were remained for the further analysis. 
RESULTS AND CONCLUSION: Three main objects are applied to bone tissue engineering, including seed cell, cytokine and scaffold. Cytokine is very important in bone tissue engineering, which including bone morphogenetic protein, transforming growth factor, vascular endothelial growth factor, fibroblast growth factor, insulin-like growth factor and platelet-derived growth factor, et al. The bone morphogenetic protein-2 and fibroblast growth factor-2 are widely used in the bone tissue engineering.

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