中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (12): 2201-2204.doi: 10.3969/j.issn.1673-8225.2010.12.028

• 生物材料综述 biomaterial review • 上一篇    下一篇

复合支架材料在脊髓组织工程中的研究与应用

崔  颖，崔志明   

  1. 南通大学第二附属医院脊柱外科，江苏省南通市   226001
  • 出版日期:2010-03-19 发布日期:2010-03-19
  • 通讯作者: 崔志明，博士，副教授，南通大学第二附属医院脊柱外科，江苏省南通市 226001
  • 作者简介:崔 颖★，男，1984年生，安徽省淮南市人，汉族，南通大学在读硕士，主要从事脊髓组织工程材料的研究。 cuiying810@sohu.com
  • 基金资助:

    课题受江苏省“医学重点人才”课题 (RC2007027)；南通市社会发展科技计划项目（S2009014）资助。

Research and application of composite scaffold materials in spinal cord tissue engineering

Cui Ying, Cui Zhi-ming   

  1. Department of Spine Surgery, Second Affiliated Hospital, Nantong University, Nantong   226001, Jiangsu Province, China
  • Online:2010-03-19 Published:2010-03-19
  • Contact: Cui Zhi-ming, Doctor, Associate professor, Department of Spine Surgery, Second Affiliated Hospital, Nantong University, Nantong 226001, Jiangsu Province, China
  • About author:Cui Ying★, Studying for master’s degree, Department of Spine Surgery, Second Affiliated Hospital, Nantong University, Nantong 226001, Jiangsu Province, China cuiying810@sohu.com
  • Supported by:

    Medical Talented People Project of Jiangsu Province, No. RC2007027*; the Scientific and Technological Project for Social Development of Nantong City, No. S2009014*

PDF

355

被引次数

3

摘要：

背景：在作为种子细胞载体的组织工程支架材料的合成与制备中，将两种或两种以上具有互补特性的支架材料组合成的复合材料支架，能够改善单一材料的不足，并保留原材料的特点。
目的：通过分析和总结1998年以来采用复合支架移植修复损伤脊髓的研究，寻求适合脊髓组织工程的新型复合材料及其适用标准。
方法：分别以“支架、脊髓损伤”，“scaffold、spinal cord injury”为检索词，应用计算机检索重庆维普(VIP)期刊全文数据库及Pubmed 数据库1998-01/2009-12有关文章。纳入有关脊髓组织工程的文献。排除与研究目的无关和内容重复者。保留32篇文献做进一步分析。
结果与结论：理想的复合生物材料支架除了应具备良好的生物相容性、可降解性、高孔隙率及机械强度外，还要具有合适的刚度、渗透性、膨胀性、降解速率以及轴突引导作用。现有的单一材料支架很难同时具备这些性能，因此对不同材料的复合搭配是解决此难题的可行方法。不论用哪些材料，所制成的复合支架都要具有生物相容性，这在宏观和微观上都影响神经轴突再生的能力和结构；对不同大小分子的渗透性是评估营养物质进入支架和代谢废物排出的关键性能；要清楚支架在脊髓水环境中的膨胀程度，使其保持在合适的位置而不压迫再生的神经。目前还在寻找这样一种完全合适的支架来治疗脊髓损伤。

关键词: 支架, 复合材料, 脊髓损伤, 组织工程, 综述文献　

Abstract:

BACKGROUND: For the composition and preparation of tissue engineering scaffolds materials which is the carrier of seed cells, two or more kinds of complementary scaffolds materials were synthesized to improve the lack of a single material and retain the characteristics of raw materials, which makes the composite scaffolds more and more popular.
OBJECTIVE: By analyzing and summarizing the research which adopts composite scaffolds to repair spinal cord injury since 1998, we devote to find suitable new spinal cord tissue engineering composite materials and their applicable standards.
METHODS: Articles addressing spinal cord tissue engineering were retrieved from VIP database and Pubmed database with the key words of “scaffold, spinal cord injury” between January 1998 and December 2009. The literature of irrelevant purpose and repetitive content were excluded, and then 30 literatures were included for final analysis.
RESULTS AND CONCLUSION: An ideal composite biological scaffold should have good biocompatibility, biodegradable, high porosity and mechanical strength, but also with appropriate stiffness, permeability, swelling, degradation rate and the axon guidance function. The existing single-material scaffold is difficult to have these properties simultaneously, so the complex mix of different materials is a feasible way to resolve this problem. The obtained composite scaffold materials must have great biocompatibility, which could influence neuraxon regeneration and structure. An evaluation of permeability in varying molecules was a key factor to determine input of nutritive materials and output of metabolic waste. Expansion of scaffold should be understood under spinal cord water environment, because the expansion might press regenerated nerve. Recently, an exactly suitable scaffold is still searching to treat spinal cord injury. 

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