关键词: 纳米药物, 纳米微粒, 药物载体, 靶向作用, 不良反应

Abstract:

OBJECTIVE: To explore targeting of nanometer drugs and the adverse reaction during disease treatment.
METHODS: The first author retrieved China National Knowledge Infrastructure with the key words of “nanometer drug, nanometer particle, drug carrier, targeting, adverse reaction” for articles published from 2001 to 2009 in Chinese. The articles addressing close content of targeting and adverse reactions of nanometer drugs were included, and Meta analysis, irrelevant or duplicated articles were excluded. Finally, 18 articles were included. We summarized the present studies concerning targeting and adverse reactions of nanometer drugs.
RESULTS: Compared with common drugs, nanometer drugs had great surface area, strong chemical activity, and rapid rate of absorption. Nanometer drugs process a superiority compared with common drugs in aspects of traversing various barriers of the body, controlling release speed of drugs, and setting drug targeting.
CONCLUSION: Compared with previous drugs, the targeting nanometer drugs present significant targeting. i.e. it can bring drugs to the targeting site. It not only can elevate curative effects, but decrease adverse reactions. Nanometer drugs as a new preparation provide a new thought for treating some refractory diseases, and bring a reformation for medical research. However, some nanometer materials show toxic properties, and especially the outcomes of interaction of nanometer materials to human or environment are still unclear. Therefore, the biological effects, action mechanism and elimination measures of toxicity of nanometer materials should be completely studied prior to the nanometer materials are made into commercialization products, which will bring a basic rationale for reasonable application of nanometer materials.